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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dhrs3tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007106
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dhrs3tm1Lex/Dhrs3tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5553308
hm2
Dhrs3tm1Lex/Dhrs3tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:5429610
ht3
Dhrs3tm1Lex/Dhrs3+ involves: 129S5/SvEvBrd * C57BL/6J MGI:5429611
cx4
Dhrs3tm1Lex/Dhrs3tm1Lex
Tg(RARE-Hspa1b/lacZ)12Jrt/0
involves: 129S5/SvEvBrd * C57BL/6 * CD-1 MGI:5553307


Genotype
MGI:5553308
hm1
Allelic
Composition
Dhrs3tm1Lex/Dhrs3tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation (3 available); any Dhrs3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the few mice that are born die soon after birth
• despite being present at close the Mendelian ratio at E14.5 and E17.5, fewer than expected mice are recovered at birth

skeleton
• at E14.5 and E17.5
• at E14.5 and E17.5
• between the atlas and axis
• at E14.5 and E17.5

cardiovascular system
• cardiac malformation in all mice at E14.5
• in 3 of 5 mice at E14.5
• in 3 of 5 mice at E14.5
• in 4 of 5 mice at E14.5

craniofacial
• at E14.5 and E17.5

homeostasis/metabolism
• altered retinoid metabolism
• however, retinaldehyde levels are normal

growth/size/body

vision/eye

behavior/neurological

digestive/alimentary system




Genotype
MGI:5429610
hm2
Allelic
Composition
Dhrs3tm1Lex/Dhrs3tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation (3 available); any Dhrs3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5429611
ht3
Allelic
Composition
Dhrs3tm1Lex/Dhrs3+
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation (3 available); any Dhrs3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• female heterozygous mice exhibited enhanced sensorimotor gating/attention during prepulse inhibition testing




Genotype
MGI:5553307
cx4
Allelic
Composition
Dhrs3tm1Lex/Dhrs3tm1Lex
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation (3 available); any Dhrs3 mutation (16 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mice exhibit severe developmental abnormalities with increased in transgene activity





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory