All Phenotypes Tg(Mov1/Tyr)OVE876BPay MGI Mouse

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder	DOID:0060041		J:167614

behavior/neurological phenotype ( J:167614 )

N	• mutants do not exhibit any head-jerking or head-tilting, and exhibit no differences from wild-type mice in swim test and contact-righting task

increased aggression towards male mice ( J:167614 )

• males begin fighting with siblings at 6-7 weeks of age: inter-male home-cage behavior during the age before stereotyping circling emerges indicates heightened aggression by mutants, with mutants engaging in tail-biting beginning at 35 days of age which was not observed for wild-type males

hyperresponsive to tactile stimuli ( J:167614 )

• mutants exhibit a lower tactile withdrawal response threshold than wild-type mice, indicating increased sensitivity to paw-touch

hyperactivity ( J:167614 )

• males consistently appear hyperactive

circling ( J:167614 )

• males display progressive circling in the home cage, that is statistically different between wild-type and mutant mice at 45 days

• rotations in mutants are in a single preferred direction, however the direction of preference differs between mice

abnormal social investigation ( J:167614 )

• in a three-chamber partition test with a male stranger mouse and a novel object, mutant males show no preference for side unlike wild-type mice which have a preference for spending time on the stranger's side relative to the side with the object

• in a direct social interaction task in which each mouse is allowed to directly interact with a naive male stranger for 10 minutes in a standard cage novel to both mice, mutant males spend significantly less time engage in active social interactions suchs sniffing or touching the stranger, than wild-type males and more time in non-social behaviors

• in the social odor test, both mutants and wild-types detect the novel odors, however, wild-type mice show increased interest relative to mutants upon first presentation of a social odor, but not for the first presentation of the second novel social odor, and both genotypes habituate to the same degree by the third presentation of the novel odors, indicating that mutants have intact olfaction but show a decrease interest in a social stimulus odor

abnormal vocalization ( J:167614 )

• pups exhibit a shift in separation-induced ultrasonic vocalization pattern, with males showing an approximate 4 day shift in the ultrasonic vocalization developmental curve, such that males do not persistently decrease their vocalizations from peak levels until P11 compared to P7 in wild-type

• however, overall total duration of calling is no different from wild-type mice

• mutants vocalize less than wild-type mice during direct social interactions

audiogenic seizures ( J:167614 )

• young males (19-21 days) are more likely to have a seizure when subjected to a loud sound stimulus compared to wild-type mice, however no spontaneous seizure activity is seen

darkened coat color ( J:167614 )

• males are more darkly and evenly pigmented than female mice

audiogenic seizures ( J:167614 )

• young males (19-21 days) are more likely to have a seizure when subjected to a loud sound stimulus compared to wild-type mice, however no spontaneous seizure activity is seen

decreased brain weight ( J:167614 )

• adult males have a lower brain weight than wild-type mice

reduced sensorimotor gating ( J:167614 )

• across a range of 17-45 days of age, males exhibit a prepulse inhibition deficit indicating impaired sensorimotor gating

decreased prepulse inhibition ( J:167614 )

• across a range of 17-45 days of age, males exhibit a prepulse inhibition deficit but no difference in acoustic startle response

darkened coat color ( J:167614 )

• males are more darkly and evenly pigmented than female mice

hearing/vestibular/ear phenotype ( J:167614 )

N	• male mutants exhibit normal auditory brainstem response at P60, indicating that hyperactivity and circling are not due to vestibular dysfunction

homeostasis/metabolism phenotype ( J:167614 )

N	• body weight and temperature regulation are no different from wild-type

taste/olfaction phenotype ( J:167614 )

N	• in a habituation/dishabituation olfactory-discrimination task, no difference in ability to differentiate between odors or ability to habituate to the odors are seen between mutants and wild-types in the nonsocial-odor test

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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