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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfil3tm1.1Kubo
targeted mutation 1.1, Masato Kubo
MGI:5005060
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo B6.Cg-Nfil3tm1.1Kubo MGI:5006685
cx2
Il10tm1Keny/Il10+
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
involves: 129 * C57BL/6 MGI:5006686


Genotype
MGI:5006685
hm1
Allelic
Composition
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic
Background
B6.Cg-Nfil3tm1.1Kubo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfil3tm1.1Kubo mutation (0 available); any Nfil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in a T cell transfer model of colitis, mice receiving T cells from knock-out mice exhibit decreased body weight and worse clinical colitis score compared with mice receiving wild-type T cells
• invariant NK T cells from the spleen or thymus co-cultured with bone marrow-derived dendritic cells exhibit reduced production of IL9, IL10. IL13, IL17a and IL22 compared with wild-type cells
• in stimulated T cells, regulatory T cells, and NKT cells (J:172134)
• in invariant NK T cells from the spleen or thymus co-cultured with bone marrow-derived dendritic cells (J:184570)
• in stimulated T cells and NKT cells (J:172134)
• in invariant NK T cells from the spleen or thymus co-cultured with bone marrow-derived dendritic cells (J:184570)
• in invariant NK T cells from the spleen or thymus co-cultured with bone marrow-derived dendritic cells
• in invariant NK T cells from the spleen or thymus co-cultured with bone marrow-derived dendritic cells
• mice fail to recover form MOG-induced experimental autoimmune encephalomyelitis unlike wild-type mice

digestive/alimentary system
• mild
• in a T cell transfer model of colitis, mice receiving T cells from knock-out mice exhibit decreased body weight and worse clinical colitis score compared with mice receiving wild-type T cells

growth/size/body
• in a T cell transfer model of colitis, mice receiving T cells from knock-out mice exhibit decreased body weight compared with mice receiving wild-type T cells




Genotype
MGI:5006686
cx2
Allelic
Composition
Il10tm1Keny/Il10+
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Keny mutation (0 available); any Il10 mutation (33 available)
Nfil3tm1.1Kubo mutation (0 available); any Nfil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following MOG-treatment, fewer Il10+ T cells are detected in the spleen, intestinal intraepithelial lymphocytes, lamina propria, and bone marrow compared to in wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory