Mouse Genome Informatics
cx1
    Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPSL)28Lpr/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 4.5 and 17 months of age (J:99507)
• abundant amyloid beta neuropil deposits in hippocampal and cortical areas in aged mice (J:128243)
• non-corrected intracranial and brain volumes are reduced compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics at 10 weeks of age
• corrected brain volumes are strongly decreased with age
• in aged mice compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• significant increase in brain length with age compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• surface area of the internal capsule does not increase with age unlike in Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• decrease in thickness of the caudal corpus callosum with age
• decrease in fornix diameter in aged mice
• age-related decline in mean synaptic bouton densities within the stratum lucidum of area CA3
• age-related decline in mean synaptic bouton densities and in mean volume
• age-related decline in mean synaptic bouton densities in area CA1?2
• clusters of swollen and abnormally distorted neuritic profiles are seen
• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer, stratum lucidum of area CA3, and stratum radiatum of area CA1?2
• global brain atrophy in aged mice

homeostasis/metabolism
• significant decrease in plasma cholesterol between 3 and 13 months of age that is not seen in wild-type controls
• plasma cholesterol levels are reduced compared to wild-type controls at 13 months of age but not at 3 months of age
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 4.5 and 17 months of age (J:99507)
• abundant amyloid beta neuropil deposits in hippocampal and cortical areas in aged mice (J:128243)

growth/size
• brain weight to body weight ratio is increased compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics at 24 months of age
• in aged mice compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:86694 , J:99507


Mouse Genome Informatics
cx2
    Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(PDGFB-APPSwDutLon)46Lpr/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

homeostasis/metabolism
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:86694


Mouse Genome Informatics
cx3
    Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0

involves: C57BL/6 * CBA * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

homeostasis/metabolism
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:86694