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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col5a3tm1Dgr
targeted mutation 1, Daniel S Greenspan
MGI:5000519
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Col5a3tm1Dgr/Col5a3tm1Dgr involves: 129S1/Sv * 129X1/SvJ * ICR MGI:5000520


Genotype
MGI:5000520
hm1
Allelic
Composition
Col5a3tm1Dgr/Col5a3tm1Dgr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col5a3tm1Dgr mutation (0 available); any Col5a3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduced thickness of the adipocyte-rich hypodermal layer of Col5a3tm1Dgr/Col5a3tm1Dgr females

endocrine/exocrine glands
• relative area of beta cells and islet density are significantly reduced in newborns
• relative area of beta cells is decreased at 3 months and 1 year of age
• at 8 to 12 weeks of age the beta cell area is reduced due to reduced islet numbers
• at 1 year of age islets are friable unlike islets from wild-type mice
• at 1 year of age about 3 fold more apoptotic cells are seen in pancreatic islets
• marked increase in the numbers of streptozotocin induced apoptotic beta cells

homeostasis/metabolism
• total body weights are lower in females on a high fat diet, but not on a normal chow diet, compared to diet matched wild-type females
• in males and females at 3 months of age and in newborns
• at 1 year of age fasting glucose levels increase to near diabetic levels
• in males and females at 3 months and 1 year of age
• in males and females at 3 months of age
• glucose intolerance appears worse at 1 year of age compared to 3 months
• in males and females at 3 months of age
• insulin resistance appears worse at 1 year of age compared to 3 months
• marked increase in the numbers of streptozotocin induced apoptotic beta cells
• marked loss of body weight in streptozotocin treated mutants compared to similarly treated controls

adipose tissue
• in females at 10 days of age
• decrease in glucose uptake in adipocytes even in the presence of relatively low insulin levels
• defect in glucose uptake increases with age

muscle
• decrease in glucose uptake in response to 100 nM insulin in soleus muscle cells from 10 to 12 week old mice
• defect in glucose uptake increases with age

growth/size/body
• total body weights are lower in females on a high fat diet, but not on a normal chow diet, compared to diet matched wild-type females
• marked loss of body weight in streptozotocin treated mutants compared to similarly treated controls
• total body weights are lower in females on a high fat diet, but not on a normal chow diet, compared to diet matched wild-type females

behavior/neurological
N
• no differences in food intake are detected

integument
• in females at 10 days of age

cellular
• decrease in glucose uptake in adipocytes even in the presence of relatively low insulin levels
• defect in glucose uptake increases with age
• at 1 year of age about 3 fold more apoptotic cells are seen in pancreatic islets
• marked increase in the numbers of streptozotocin induced apoptotic beta cells
• decrease in glucose uptake in response to 100 nM insulin in soleus muscle cells from 10 to 12 week old mice
• defect in glucose uptake increases with age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory