Mouse Genome Informatics
ht1
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• decreased survival compared to wild-type controls carrying either Tg(MMTV-cre)1Mam or Tg(MMTV-cre)4Mam

cardiovascular system
• some mice develop blood vessel lesions


Mouse Genome Informatics
cn2
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)4Mam/0

involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most die early with lymphoma/thymoma

tumorigenesis
• some mice have small mammary tumors


Mouse Genome Informatics
cn3
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)4Mam/0

involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• survival is reduced compared to mutant mice wild-type for Trp53

tumorigenesis
• at a lower rate than in mutant mice homozygous for Trp53tm1Brn
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:170898


Mouse Genome Informatics
cn4
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)1Mam/0

involves: 129S6/SvEvTac * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• survival time is reduced compared to mutant mice carrying Tg(MMTV-cre)4Mam

tumorigenesis
• develop a more diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)4Mam
• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death


Mouse Genome Informatics
cn5
    Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)4Mam/0

involves: 129S6/SvEvTac * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam

tumorigenesis
• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam
• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:170898