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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
targeted mutation 1, Sean E Egan
MGI:5000472
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac MGI:5000475
cn2
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * CD-1 MGI:5784674
cn3
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
Trp53tm1Brn/Trp53+
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:5000479
cn4
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Tfln/0
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:5000478
cn5
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
involves: 129S6/SvEvTac MGI:5000477
cn6
Arid1atm1.1Mag/Arid1atm1.1Mag
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * CD-1 MGI:5784677
cn7
Arid1atm1.1Mag/Arid1a+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * CD-1 MGI:5784679
cn8
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)1Mam/0
involves: 129S6/SvEvTac * FVB/N MGI:5000476


Genotype
MGI:5000475
ht1
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival compared to wild-type controls carrying either Tg(MMTV-cre)1Mam or Tg(MMTV-cre)4Mam

cardiovascular system
• some mice develop blood vessel lesions




Genotype
MGI:5784674
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice injected intrabursally with an adenovirus expressing cre recombinase (AdCre) exhibit multifocal sites of epithelial hyperplasia in the ovarian surface epithelium

neoplasm
N
• however, intrabursally AdCre injected mice do not form ovarian tumors

reproductive system
• mice injected intrabursally with an adenovirus expressing cre recombinase (AdCre) exhibit multifocal sites of epithelial hyperplasia in the ovarian surface epithelium




Genotype
MGI:5000479
cn3
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
Trp53tm1Brn/Trp53+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
Tg(MMTV-cre)#Tfln mutation (0 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan

endocrine/exocrine glands
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan

mortality/aging
• survival is reduced compared to mutant mice wild-type for Trp53

neoplasm
• 80% of mice have mammary tumors
• many mice have tumors in more than one gland
• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma
• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
• at a lower rate than in mutant mice homozygous for Trp53tm1Brn

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:170898




Genotype
MGI:5000478
cn4
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Tfln/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
Tg(MMTV-cre)#Tfln mutation (0 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• some mice have small mammary tumors

endocrine/exocrine glands
• some mice have small mammary tumors

mortality/aging
• most die early with lymphoma/thymoma

neoplasm
• some mice have small mammary tumors




Genotype
MGI:5000477
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)#Tfln/0
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
Tg(MMTV-cre)#Tfln mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases

endocrine/exocrine glands
• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma
• isolated lung metastases are seen in rare cases

mortality/aging
• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam

neoplasm
• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam
• isolated lung metastases are seen in rare cases
• start to develop by 5 months of age in both virgin and multiparous mice
• 69% of mice have palpable mammary tumors at the time of death
• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:170898




Genotype
MGI:5784677
cn6
Allelic
Composition
Arid1atm1.1Mag/Arid1atm1.1Mag
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid1atm1.1Mag mutation (0 available); any Arid1a mutation (146 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa rapidly develop primary ovarian tumors
• treatment of isolated tumor cells with the pan-class I PI3K inhibitor, Buparlisib, results in reduced tumor cell viability
• treatment of mice with Buparlisib for 3 weeks starting at week 4 post AdCre injection extends the median latency period of ovarian tumors by 3.5 weeks
• ovarian tumors of intrabursally AdCre injected mice are predominately solid with some papillary areas, exhibit elongated spindle-shaped cells with vacuolated cytoplasm embedded in hyalinized matrix, appear poorly differentiated and highly disorganized, and have a hobnail appearance, indicating they resemble human ovarian clear-cell carcinoma

homeostasis/metabolism
• intrabursally AdCre injected mice exhibit hemorrhagic ascites

immune system
• AdCre treated mice that have tumors exhibit high levels of secreted IL-6 in body fluids and ascitic fluid aspirates

neoplasm
• mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa rapidly develop primary ovarian tumors
• treatment of isolated tumor cells with the pan-class I PI3K inhibitor, Buparlisib, results in reduced tumor cell viability
• treatment of mice with Buparlisib for 3 weeks starting at week 4 post AdCre injection extends the median latency period of ovarian tumors by 3.5 weeks
• ovarian tumors of intrabursally AdCre injected mice are predominately solid with some papillary areas, exhibit elongated spindle-shaped cells with vacuolated cytoplasm embedded in hyalinized matrix, appear poorly differentiated and highly disorganized, and have a hobnail appearance, indicating they resemble human ovarian clear-cell carcinoma
• peritoneal metastases are seen in about 50% of mice injected with AdCre in the ovarian bursa

reproductive system
• mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa rapidly develop primary ovarian tumors
• treatment of isolated tumor cells with the pan-class I PI3K inhibitor, Buparlisib, results in reduced tumor cell viability
• treatment of mice with Buparlisib for 3 weeks starting at week 4 post AdCre injection extends the median latency period of ovarian tumors by 3.5 weeks
• ovarian tumors of intrabursally AdCre injected mice are predominately solid with some papillary areas, exhibit elongated spindle-shaped cells with vacuolated cytoplasm embedded in hyalinized matrix, appear poorly differentiated and highly disorganized, and have a hobnail appearance, indicating they resemble human ovarian clear-cell carcinoma

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:219794




Genotype
MGI:5784679
cn7
Allelic
Composition
Arid1atm1.1Mag/Arid1a+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid1atm1.1Mag mutation (0 available); any Arid1a mutation (146 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 5 of 7 mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa exhibit ovarian surface epithelium hyperplasia

neoplasm
N
• however, intrabursally AdCre injected mice do not form ovarian tumors

reproductive system
• 5 of 7 mice injected with an adenovirus expressing cre recombinase (AdCre) in the ovarian bursa exhibit ovarian surface epithelium hyperplasia




Genotype
MGI:5000476
cn8
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Tg(MMTV-cre)1Mam/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (343 available)
Tg(MMTV-cre)1Mam mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death

endocrine/exocrine glands
• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death

mortality/aging
• survival time is reduced compared to mutant mice carrying Tg(MMTV-cre)4Mam

neoplasm
• develop a more diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)4Mam
• start to develop by 5 months of age in both virgin and multiparous mice
• 42% of mice have palpable mammary tumors at the time of death





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory