Mouse Genome Informatics
tg1
    Tg(AR*100Q)C32Als/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die of unknown causes at 20 to 24 months of age

behavior/neurological
• at 18 months, male mice exhibit impaired gait compared with control mice
• however, female mice do not exhibit impaired gait
• however, female mice do not exhibit severe hindlimb paralysis
• at 22 months, male mice exhibit hindlimb paralysis unlike control mice

growth/size/body
• beginning at 12 months of age in male mice and 22 months of age in female mice
• beginning at 12 months of age in male mice and 22 months of age in female mice

muscle
• at 18 months, male mice exhibit hindlimb atrophy unlike control mice
• however, female mice do not exhibit severe hindlimb atrophy

Mouse Models of Human Disease
OMIM IDRef(s)
Spinal and Bulbar Muscular Atrophy, X-Linked 1; SMAX1 313200 J:89772