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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xpnpep1Gt(S22-1B1)Sor
gene trap S22-1B1, Philippe Soriano
MGI:4973607
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xpnpep1Gt(S22-1B1)Sor/Xpnpep1Gt(S22-1B1)Sor B6.129S4-Xpnpep1Gt(S22-1B1)Sor MGI:5495163
hm2
 		Xpnpep1Gt(S22-1B1)Sor/Xpnpep1Gt(S22-1B1)Sor involves: 129S4/SvJae * C57BL/6J MGI:5495164


Genotype
MGI:5495163
hm1
Allelic
Composition		 Xpnpep1Gt(S22-1B1)Sor/Xpnpep1Gt(S22-1B1)Sor
Genetic
Background		 B6.129S4-Xpnpep1Gt(S22-1B1)Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpnpep1Gt(S22-1B1)Sor mutation (0 available); any Xpnpep1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:193753 )
• mice do not survive beyond 3 days after birth




Genotype
MGI:5495164
hm2
Allelic
Composition		 Xpnpep1Gt(S22-1B1)Sor/Xpnpep1Gt(S22-1B1)Sor
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpnpep1Gt(S22-1B1)Sor mutation (0 available); any Xpnpep1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal survival ( J:193753 )
• male mice exhibit reduced survival compared with female mice
prenatal lethality, incomplete penetrance ( J:193753 )
• fewer than expected mice are produced from heterozygotes

growth/size/body
decreased birth body size ( J:193753 )
microcephaly ( J:193753 )
decreased body size ( J:193753 )
decreased body weight ( J:193753 )
decreased body length ( J:193753 )
postnatal growth retardation ( J:193753 )
• in male and female mice without a difference between gender growth rates unlike in wild-type mice

nervous system
forebrain hypoplasia ( J:193753 )
• reduced width, length and thickness

homeostasis/metabolism
abnormal urine color ( J:193753 )
• slightly dark urine

renal/urinary system
abnormal urine color ( J:193753 )
• slightly dark urine




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory