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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rnf168Gt(156B6)Cmhd
gene trap 156B6, Centre for Modeling Human Disease
MGI:4970574
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5505899
cx2
Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd
Trp53tm1Brd/Trp53tm1Brd
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:5505906


Genotype
MGI:5505899
hm1
Allelic
Composition
Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf168Gt(156B6)Cmhd mutation (0 available); any Rnf168 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• increased vacuolization at 12 months
• lack or reduced number of spermatids in seminiferous tubules at 12 months
• increased vacuolization at 12 months
• at 12 months but not 8 weeks
• at 12 months but not 8 weeks
• at 12 months but not 8 weeks

immune system
N
• T cell and stimulated B cell proliferation is normal
• directly impaired class switch recombination
• lower frequency of Smu-Sgamma1 switch recombination
• increased frequency of long nucleotide insertions at the class switch recombination junctions
• at 6 to 8 weeks and 9 to 12 months
• fewer IgG1-expressing B cells in Peyer's patches
• reduced secretion from B cells stimulated with LPS and IL4
• reduced secretion from B cells stimulated with LPS and IL4
• fewer IgG3-expressing B cells in Peyers patches
• reduced secretion from B cells stimulated with LPS and IL4

cellular
• increased vacuolization at 12 months
• lack or reduced number of spermatids in seminiferous tubules at 12 months
• irradiated mouse embryonic fibroblasts accumulate at the G2/M phase
• however, activation of the G1/S checkpoint is normal
• spontaneous chromosome aberration in LPS stimulated B cells
• following exposure to ionizing radiation

neoplasm
N
• mice do not develop tumors over a 1 year period

endocrine/exocrine glands
• increased vacuolization at 12 months
• at 12 months but not 8 weeks
• at 12 months but not 8 weeks

hematopoietic system
• directly impaired class switch recombination
• lower frequency of Smu-Sgamma1 switch recombination
• increased frequency of long nucleotide insertions at the class switch recombination junctions
• at 6 to 8 weeks and 9 to 12 months
• fewer IgG1-expressing B cells in Peyer's patches
• reduced secretion from B cells stimulated with LPS and IL4
• reduced secretion from B cells stimulated with LPS and IL4
• fewer IgG3-expressing B cells in Peyers patches
• reduced secretion from B cells stimulated with LPS and IL4

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
RIDDLE syndrome DOID:0090113 OMIM:611943
J:198260




Genotype
MGI:5505906
cx2
Allelic
Composition
Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf168Gt(156B6)Cmhd mutation (0 available); any Rnf168 mutation (73 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit decreased tumor free survival compared with Trp53tm1Brd homozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory