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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PDGFB-LRRK2*G2019S)340Djmo
transgene insertion 340, Darren Moore
MGI:4950671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(PDGFB-LRRK2*G2019S)340Djmo/0 involves: C3H/HeJ * C57BL/6J MGI:5300181


Genotype
MGI:5300181
tg1
Allelic
Composition
Tg(PDGFB-LRRK2*G2019S)340Djmo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PDGFB-LRRK2*G2019S)340Djmo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Progressive loss of substantia nigra dopaminergic neurons in Tg(PDGFB-LRRK2*G2019S)340Djmo/0 transgenic mice

nervous system
• neuronal soma from the cerebral cortex and striatum of 17-18 month old mice exhibit condensed aggregated mitochondria, damaged mitochondria and an increase in the density of autophagic vacuoles
• by 19-21 months, transgenic mice exhibit an 18% loss of TH+ dopaminergic neurons and a 17% loss of Nissl+ nigral neurons in the substantia nigra pars compacta
• dopaminergic neuritic density is reduced by 14% in substantia nigra pars reticulata, but not in the striatum
• normal numbers of dopaminergic neurons are observed in the ventral tegemental area
• cultured dopaminergic neurons exhibit a reduction in neurite complexity characterized by shorter neurites and reduced branching at 7 days in vitro
• neurite branching is slightly increased at 6 days in vitro
• axonal processes from the cerebral cortex and striatum of 17-18 month old mice contain an increase in the density of autophagic vacuoles

homeostasis/metabolism
• observed in the brain of aged mice
• dopamine turnover is increased in 14-15 month old mice
• levels of the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), are decreased in the olfactory bulb at 14-15 months of age, however, dopamine levels are not increased
• mice exhibit a small, but significant, increase in serotonin levels

cellular
• observed in the brain of aged mice





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory