Phenotypes associated with this allele

• Allele Symbol: Otof^tm1.1Erei
• Allele Name: targeted mutation 1.1, Ellen Reisinger
• Allele ID: MGI:4950055
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otof^tm1.1Erei/Otof^tm1.1Erei	involves: 129P2/OlaHsd	MGI:4950851

Genotype
MGI:4950851

hm1

• Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:171203 )

N • spontaneous and evoked exocytosis in hippocampal neurons is normal

abnormal cochlear inner hair cell physiology ( J:171203 )

• mature inner hair cells exhibit impaired exocytosis compared with heterozygous mice that cannot be restored by over-expression of Syt1

abnormal miniature excitatory postsynaptic currents ( J:171203 )

• the frequency and amplitude of miniature excitatory postsynaptic currents is unchanged by TTX treatment unlike in wild-type mice

hearing/vestibular/ear

abnormal cochlear inner hair cell physiology ( J:171203 )

• mature inner hair cells exhibit impaired exocytosis compared with heterozygous mice that cannot be restored by over-expression of Syt1

increased or absent threshold for auditory brainstem response ( J:171203 )

• mice fail to exhibit any brainstem auditory evoked potential unlike heterozygous mice that cannot be restored by over-expression of Syt1