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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Otoftm1.1Erei
targeted mutation 1.1, Ellen Reisinger
MGI:4950055
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Otoftm1.1Erei/Otoftm1.1Erei involves: 129P2/OlaHsd MGI:4950851


Genotype
MGI:4950851
hm1
Allelic
Composition
Otoftm1.1Erei/Otoftm1.1Erei
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otoftm1.1Erei mutation (0 available); any Otof mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• spontaneous and evoked exocytosis in hippocampal neurons is normal
• mature inner hair cells exhibit impaired exocytosis compared with heterozygous mice that cannot be restored by over-expression of Syt1
• the frequency and amplitude of miniature excitatory postsynaptic currents is unchanged by TTX treatment unlike in wild-type mice

hearing/vestibular/ear
• mature inner hair cells exhibit impaired exocytosis compared with heterozygous mice that cannot be restored by over-expression of Syt1
• mice fail to exhibit any brainstem auditory evoked potential unlike heterozygous mice that cannot be restored by over-expression of Syt1





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory