Phenotypes associated with this allele
Allelic Composition |
Mecp2tm1Vnar/Mecp2+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Vnar mutation
(0 available);
any
Mecp2 mutation
(38 available)
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mortality/aging
N |
• mice live longer than 14 months with no unusual health issues
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reproductive system
N |
• mice exhibit normal fertility
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behavior/neurological
N |
• mice do not exhibit seizures or tremors
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Allelic Composition |
Mecp2tm1Vnar/Y
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Vnar mutation
(0 available);
any
Mecp2 mutation
(38 available)
|
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Frontal cortex and olfactory bulbs of Mecp2tm1Vnar/Y mice exhibit an increase in cell density
mortality/aging
N |
• mice live longer than 14 months with no unusual health issues
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reproductive system
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• mice do not successfully reproduce
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nervous system
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• cell density in the CA1, CA2, and CA3 of the hippocampus is increased compared to in wild-type mice
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• cell density in the dentate gyrus is increased compared to in wild-type mice
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• cell density in the frontal cortex is increased compared to in wild-type mice
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• cell density in the olfactory bulb is increased compared to in wild-type mice
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• cell density in the cerebellum is increased compared to in wild-type mice
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• cell density in the granule cell layer of the cerebellum is increased compared to in wild-type mice
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• cortical neurons exhibit abnormal dendritic branching and decreased dendritic complexity compared with wild-type neurons
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behavior/neurological
N |
• mice do not exhibit seizures or tremors
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growth/size/body
N |
• mice exhibit normal weight gain
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