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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
targeted mutation 2, Guoping Feng
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
Shank3tm2Gfng/Shank3tm2Gfng involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4949761

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm2Gfng mutation (1 available); any Shank3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• mice exhibit normal learning and memory in a Morris water maze
• mice exhibit less time exploring the open arms of an elevated plus maze compared with wild-type mice
• mice exhibit increased latency to crossing a bright area in a light-dark emergence test compared with wild-type mice
• however, mice exhibit normal thigmotaxis in an open field and time spent on either side of the box in the light-dark emergence test
• resulting in skin lesions
• mice prefer to interact with an empty cage rather than a social partner unlike wild-type mice
• mice spend less time interacting with a social partner than wild-type mice
• mice fail to spend more time with a novel social partner unlike wild-type mice
• social withdrawal is not alleviated by cross fostering pups with wild-type dams
• mice occasionally exhibit handling-induced seizures unlike wild-type mice
• however, no spontaneous seizures are observed

nervous system
• mice occasionally exhibit handling-induced seizures unlike wild-type mice
• however, no spontaneous seizures are observed
• mice exhibit striatal hypertrophy compared with wild-type mice
• medium spiny neurons exhibit neuronal hypertrophy with increased complexity of dendritic arborization, total dendritic length, and surface area compared to in wild-type mice
• spine density is reduced compared to in wild-type mice
• the neck width of medium spiny neuron spines is slightly larger than in wild-type mice
• mice exhibit abnormal post-synaptic density composition compared to in wild-type mice
• reduced frequency and peak amplitude in medium spiny neurons
• however, miniature excitatory postsynaptic current frequency and amplitude in the hippocampal CA1 sub-region are normal

• at 3 to 6 months of age, mice exhibit pronounced skin lesions with varying degrees of penetrance due to excessive self-grooming unlike wild-type mice

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory