All Phenotypes Crp<tm1Hjf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crp^tm1Hjf
targeted mutation 1, H J Fehling
MGI:4947397

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crp^tm1Hjf/Crp^tm1Hjf	C57BL/6-Crp^tm1Hjf	MGI:4947398
ht2	Crp^tm1Hjf/Crp⁺	C57BL/6-Crp^tm1Hjf	MGI:4947399
cx3	Apoe^tm1Unc/Apoe^tm1Unc Crp^tm1Hjf/Crp^tm1Hjf	B6.Cg-Crp^tm1Hjf Apoe^tm1Unc	MGI:4947400
cx4	Crp^tm1Hjf/Crp^tm1Hjf Ldlr^tm1Her/Ldlr^tm1Her	B6.Cg-Crp^tm1Hjf Ldlr^tm1Her	MGI:4947401

Allelic Composition	Crp^tm1Hjf/Crp^tm1Hjf
Genetic Background	C57BL/6-Crp^tm1Hjf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crp^tm1Hjf mutation (1 available); any Crp mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are undetectable unlike in wild-type mice

immune system

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are undetectable unlike in wild-type mice

Allelic Composition	Crp^tm1Hjf/Crp⁺
Genetic Background	C57BL/6-Crp^tm1Hjf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crp^tm1Hjf mutation (1 available); any Crp mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are reduced by half compared to in wild-type mice

immune system

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are reduced by half compared to in wild-type mice

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Crp^tm1Hjf/Crp^tm1Hjf
Genetic Background	B6.Cg-Crp^tm1Hjf Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Crp^tm1Hjf mutation (1 available); any Crp mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 16 weeks of age

increased circulating HDL cholesterol level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 16 weeks of age

decreased circulating triglyceride level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 12 weeks of age

cardiovascular system

increased susceptibility to atherosclerosis ( J:170409 )

• at 12 weeks of age, female mice fed a low-fat, semi-synthetic diet exhibit an increase in susceptibility to atherosclerosis in the aortic root compared with Apoe^tm1Unc homozygotes

• at 16 weeks of age, male mice fed a low-fat, semi-synthetic diet exhibit an increase in susceptibility to atherosclerosis in the aortic root compared with Apoe^tm1Unc homozygotes

Allelic Composition	Crp^tm1Hjf/Crp^tm1Hjf Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	B6.Cg-Crp^tm1Hjf Ldlr^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crp^tm1Hjf mutation (1 available); any Crp mutation (16 available)
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating LDL cholesterol level ( J:170409 )

• in male mice at 20 weeks

decreased circulating VLDL cholesterol level ( J:170409 )

• in male mice at 20 weeks

increased circulating cholesterol level ( J:170409 )

• in male mice at 20 weeks

increased circulating triglyceride level ( J:170409 )

• in male mice at 20 weeks

cardiovascular system

atherosclerotic lesions ( J:170409 )

• female mice exhibit an increase in macrophage content in lesions compared with Ldlr^tm1Her homozygotes

• however, lesion size and susceptibility do not differ from Ldlr^tm1Her homozygotes

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