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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Csgalnact1tm1.1Nari
targeted mutation 1.1, Hisashi Narimatsu
MGI:4947395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari involves: C57BL/6J MGI:4947396
cx2
Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
involves: C57BL/6J MGI:6117388


Genotype
MGI:4947396
hm1
Allelic
Composition
Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csgalnact1tm1.1Nari mutation (0 available); any Csgalnact1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit a normal lifespan

reproductive system
N
• mice exhibit normal reproduction

skeleton
N
• mice exhibit normal chondrocyte proliferation and differentiation
• humerus cartilage exhibit decreased extracellular matrix and densely packed proliferative chondrocytes compared to in wild-type mice (J:170410)
• Safranin-O staining indicates slightly decreased glycosaminoglycan content (J:256718)
• reduced chondroitin sulfate content (J:256718)
• mice exhibit decreased proliferative chondrocytes compared to in wild-type mice
• chondrocyte columns are disorganized compared to in wild-type mice

growth/size/body
• a few days after birth

limbs/digits/tail




Genotype
MGI:6117388
cx2
Allelic
Composition
Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csgalnact1tm1.1Nari mutation (0 available); any Csgalnact1 mutation (33 available)
Csgalnact2tm1.2Staka mutation (0 available); any Csgalnact2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• do not survive after birth

respiratory system
• when delivered by cesarean section pups struggle to initiate breathing
• no alveolar air spaces in the lungs indicating mice die of respiratory failure

homeostasis/metabolism

growth/size/body
• slightly lower

skeleton
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote
• Safranin-O staining indicates drastically decreased glycosaminoglycan content

limbs/digits/tail
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote
• length is reduced by 22% compared to controls
• decreased bone length is not seen in either single homozygote





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory