About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rhotm1.1Kpal
targeted mutation 1.1, Krzysztof Palczewski
MGI:4947230
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rhotm1.1Kpal/Rhotm1.1Kpal involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947237
ht2
Rhotm1.1Kpal/Rho+ involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947235
cx3
Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M
involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4947236


Genotype
MGI:4947237
hm1
Allelic
Composition
Rhotm1.1Kpal/Rhotm1.1Kpal
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation (1 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice

vision/eye
• at P63, photoreceptor cells are almost gone unlike in wild-type mice

nervous system
• at P63, photoreceptor cells are almost gone unlike in wild-type mice




Genotype
MGI:4947235
ht2
Allelic
Composition
Rhotm1.1Kpal/Rho+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation (1 available); any Rho mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice

vision/eye
• the distance between retina pigmented epithelium and the outer limiting membrane is reduced compared to in wild-type mice
• half the number in wild-type mice
• due to necrosis
• mildly reduced at P70
• severely depressed at P170
• continuous decline until P276
• severely reduced at P41
• nearly undetectable by P170

nervous system
• half the number in wild-type mice
• due to necrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:170648




Genotype
MGI:4947236
cx3
Allelic
Composition
Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrattm1Kpal mutation (1 available); any Lrat mutation (19 available)
Rhotm1.1Kpal mutation (1 available); any Rho mutation (37 available)
Rpe65450L mutation (0 available); any Rpe65 mutation (32 available)
Rpe65450M mutation (0 available); any Rpe65 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Effect of genetic depletion of 11-cis-retinal production (Lrattm1Kpal/Lrattm1Kpal) on retinal degeneration in Rhotm1.1Kpal/Rho+ mice

vision/eye
• dramatically reduced at P36
• less than in Rhotm1.1Kpal heterozygotes
• due to increased apoptosis
• less than in Rhotm1.1Kpal heterozygotes

nervous system
• dramatically reduced at P36
• less than in Rhotm1.1Kpal heterozygotes
• due to increased apoptosis
• less than in Rhotm1.1Kpal heterozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2022
MGI 6.20
The Jackson Laboratory