Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation
(1 available);
any
Rho mutation
(48 available)
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Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice
vision/eye
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• at P63, photoreceptor cells are almost gone unlike in wild-type mice
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nervous system
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• at P63, photoreceptor cells are almost gone unlike in wild-type mice
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Allelic Composition |
Rhotm1.1Kpal/Rho+
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Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 * FVB/N |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Kpal mutation
(1 available);
any
Rho mutation
(48 available)
|
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Retinal degeneration in Rhotm1.1Kpal/Rho+ and Rhotm1.1Kpal/Rhotm1.1Kpal mice
vision/eye
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• the distance between retina pigmented epithelium and the outer limiting membrane is reduced compared to in wild-type mice
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• half the number in wild-type mice
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• shortened at P35 and P112
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• continuous decline until P276
• mildly reduced at P70
• severely depressed at P170
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• severely reduced at P41
• nearly undetectable by P170
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nervous system
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• half the number in wild-type mice
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• shortened at P35 and P112
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Effect of genetic depletion of 11-cis-retinal production (Lrattm1Kpal/Lrattm1Kpal) on retinal degeneration in Rhotm1.1Kpal/Rho+ mice
vision/eye
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• dramatically reduced at P36
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• less than in Rhotm1.1Kpal heterozygotes
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• due to increased apoptosis
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• less than in Rhotm1.1Kpal heterozygotes
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nervous system
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• dramatically reduced at P36
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• less than in Rhotm1.1Kpal heterozygotes
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• due to increased apoptosis
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• less than in Rhotm1.1Kpal heterozygotes
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