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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lig3tm1.1Pmc
targeted mutation 1.1, Peter J McKinnon
MGI:4946931
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Lig3tm1.1Pmc/Lig3tm1.1Pmc
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6 * FVB MGI:4946937
cn2
Lig3tm1.1Pmc/Lig3tm1.1Pmc
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL MGI:4946935


Genotype
MGI:4946937
cn1
Allelic
Composition
Lig3tm1.1Pmc/Lig3tm1.1Pmc
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig3tm1.1Pmc mutation (0 available); any Lig3 mutation (28 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 3.5 and 4.5 weeks of age

cardiovascular system
• with abnormal mitochondria
• mice exhibit decreased diastolic and systolic movements of the left ventricle wall and interventricular septum compared with wild-type mice
• fractional shortening and ejection fraction are decreased compared to in wild-type mice

muscle
• with abnormal mitochondria
• fractional shortening and ejection fraction are decreased compared to in wild-type mice




Genotype
MGI:4946935
cn2
Allelic
Composition
Lig3tm1.1Pmc/Lig3tm1.1Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig3tm1.1Pmc mutation (0 available); any Lig3 mutation (28 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond 20 days of age

nervous system
• granule neuron progenitors exhibit reduced proliferation and increased apoptosis compared to in wild-type mice
• reduced in the cerebellum
• cortical astrocytes exhibit mitochondrial defects, decreased mitochondrial DNA, and increased lactic acid compared to in wild-type mice
• DNA repair in response to ultraviolet irradiation or methylmethanesulphonate compared with wild-type astrocyte
• however, astrocytes exhibit normal DNA repair in response to ionizing radiation and hydrogen peroxide

cellular
• DNA repair in response to ultraviolet irradiation or methylmethanesulphonate compared with wild-type astrocyte
• however, astrocytes exhibit normal DNA repair in response to ionizing radiation and hydrogen peroxide
• granule neuron progenitors exhibit reduced proliferation and increased apoptosis compared to in wild-type mice
• reduced in the cerebellum
• brain cells exhibit defective mitochondria complex I activity and reduced oxidative metabolism compared with wild-type cells

growth/size/body
• at 2 weeks of age

behavior/neurological
• at 2 weeks of age

homeostasis/metabolism
• DNA repair in response to ultraviolet irradiation or methylmethanesulphonate compared with wild-type astrocyte
• however, astrocytes exhibit normal DNA repair in response to ionizing radiation and hydrogen peroxide





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory