Phenotypes associated with this allele

• Allele Symbol: Rsad2^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:4943550
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rsad2^tm1Aki/Rsad2^tm1Aki	involves: 129/Sv * C57BL/6	MGI:4943556

Genotype
MGI:4943556

hm1

• Allelic Composition: Rsad2^tm1Aki/Rsad2^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased circulating interferon-alpha level ( J:169840 )

• induced by A- and D-type CpG DNA

decreased interferon-alpha secretion ( J:169840 )

• in splenic dendritic cells induced by A- and D-type CpG DNA

decreased interferon-beta secretion ( J:169840 )

• after TLR7 engagement with heat-treated Newcastle disease virus or TLR9 engagement by CpG DNA in FLT3L-induced dendritic cells

• however, IFN-beta production is normal in response to dsRNA and dsDNA transfection of mouse embryonic fibroblasts, and mouse infection with NDV, encephalomyocarditis virus, L. monocytogenes, or herpes simplex virus 1

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:169840 )

• induced by A- and D-type CpG DNA