About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak
transposon insertion IR3.PV384, Junji Takeda
MGI:4941776
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak involves: C3H * C57BL/6J * DBA/2 MGI:4941783
hm2
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak involves: C3H * C57BL/6J * DBA/2 * ICR MGI:4941784


Genotype
MGI:4941783
hm1
Allelic
Composition
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak
Genetic
Background
involves: C3H * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak mutation (2 available); any Smoc1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive beyond 3 weeks

limbs/digits/tail
• at E13.5 and E14.5, apoptosis cells in the mesenchyme between digits 2 and 3 and digits 3 and 4 is reduced with persistent webbing compared to in wild-type mice
• soft tissue syndactyly at birth and P14
• at E13.5 and E14.5, apoptosis cells in the mesenchyme between digits 2 and 3 and digits 3 and 4 is reduced with persistent webbing compared to in wild-type mice
• in all mice at P0 and at P14
• the tibia/fibula and calcanea joint is malpositioned compared to in wild-type mice
• mice exhibit pes valgus (foot bent outward at the talocalcanean joint) in the hind limb unlike wild-type mice
• mice exhibit stenosis between the fourth and fifth metatarsal unlike wild-type mice

vision/eye
• in some mice
• at P0 and P14, optic diameter is reduced compared to in wild-type mice
• at E14.5, 11 of 12 eyes exhibit atrophy of the anteroventral part of the retina compared with wild-type mice
• at E14.5, 10 of 12 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
• at P0, 3 of 6 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
• at P0, all eyes exhibit retinal atrophy unlike wild-type mice

growth/size/body
• at P0 and P14

craniofacial

skeleton
• mice exhibit stenosis between the fourth and fifth metatarsal unlike wild-type mice
• the tibia/fibula and calcanea joint is malpositioned compared to in wild-type mice
• mice exhibit stenosis between the fourth and fifth metatarsal unlike wild-type mice

nervous system
• in some mice
• at P0 and P14, optic diameter is reduced compared to in wild-type mice

pigmentation
• at E14.5, 10 of 12 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice
• at P0, 3 of 6 eyes exhibit an extension of the retinal pigmented epithelium to the optic nerve unlike wild-type mice

digestive/alimentary system

cellular
• at E13.5 and E14.5, apoptosis cells in the mesenchyme between digits 2 and 3 and digits 3 and 4 is reduced with persistent webbing compared to in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microphthalmia with limb anomalies DOID:0060861 OMIM:206920
J:169180




Genotype
MGI:4941784
hm2
Allelic
Composition
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak
Genetic
Background
involves: C3H * C57BL/6J * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smoc1Tn(sb-lacZ,GFP)IR3.PV384Jtak mutation (2 available); any Smoc1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• four digits with four phalanx and five metatarsals in the hind limb
• two-thirds of forelimbs exhibit soft tissue syndactyly unlike wild-type mice
• in 13 of 17 mice at P0

craniofacial
• in 3 of 17 mice

digestive/alimentary system
• in 3 of 17 mice

growth/size/body
• in 3 of 17 mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory