Phenotypes associated with this allele

• Allele Symbol: Lamc3^tm1.1Wjbr
• Allele Name: targeted mutation 1.1, William J Brunken
• Allele ID: MGI:4941480
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lamc3^tm1.1Wjbr/Lamc3^tm1.1Wjbr	involves: 129X1/SvJ * C57BL/6J	MGI:4941481
cx2	Lamb2^tm1Jrs/Lamb2^tm1Jrs Lamc3^tm1.1Wjbr/Lamc3^tm1.1Wjbr	B6.129-Lamc3^tm1.1Wjbr Lamb2^tm1Jrs	MGI:4941482

Genotype
MGI:4941481

hm1

• Allelic Composition: Lamc3^tm1.1Wjbr/Lamc3^tm1.1Wjbr
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal amacrine cell morphology ( J:169656 )

• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat larger compared to wild-type controls

nervous system

abnormal amacrine cell morphology ( J:169656 )

• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat larger compared to wild-type controls

Genotype
MGI:4941482

cx2

• Allelic Composition: Lamb2^tm1Jrs/Lamb2^tm1Jrs; Lamc3^tm1.1Wjbr/Lamc3^tm1.1Wjbr
• Genetic Background: B6.129-Lamc3^tm1.1Wjbr Lamb2^tm1Jrs

vision/eye

abnormal retina morphology ( J:169656 )

• at P20 the basement membrane shows local disruptions in its structure

abnormal Muller cell morphology ( J:169656 )

• at the sites of breaks in the basement membrane, Muller cell basal terminals form a disorganized array from the inner plexiform layer (IPL) through the ganglion cell layer

• at other points, Muller cell terminals form aggregates at blood vessels

• the overall length is reduced and the fine lateral branches within the IPL are disarrayed

• at P12, the vertical shafts are thinner in the regions of basement membrane breaks

abnormal amacrine cell morphology ( J:169656 )

• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat smaller compared to wild-type controls and both single null mice

• however, no abnormalities are detected in cholinergic or AII amacrine cells

decreased amacrine cell number ( J:169656 )

• decrease in the density of type I TH neurons at P20

abnormal retina development ( J:169656 )

• the delay in the increase in density of type I TH neurons detected between P3 and P5 is increased compared to mice homozygous null for Lamb2 alone

abnormal eye physiology ( J:169656 )

• the tyrosine hydroxylase immunoreactivity of type II amacrine cells is increased at P20

nervous system

abnormal Muller cell morphology ( J:169656 )

• at the sites of breaks in the basement membrane, Muller cell basal terminals form a disorganized array from the inner plexiform layer (IPL) through the ganglion cell layer

• at other points, Muller cell terminals form aggregates at blood vessels

• the overall length is reduced and the fine lateral branches within the IPL are disarrayed

• at P12, the vertical shafts are thinner in the regions of basement membrane breaks

abnormal amacrine cell morphology ( J:169656 )

• at P20, the perikarya of type I tyrosine hydroxylase expressing (TH) neurons are somewhat smaller compared to wild-type controls and both single null mice

• however, no abnormalities are detected in cholinergic or AII amacrine cells

decreased amacrine cell number ( J:169656 )

• decrease in the density of type I TH neurons at P20