All Phenotypes Hand2<tm2.1Dsr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hand2^tm2.1Dsr
targeted mutation 2.1, Deepak Srivastava
MGI:4940061

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand2^tm2.1Dsr/Hand2^tm2.1Dsr	involves: 129 * C57BL/6	MGI:4940097
cn2	Hand2^tm1Dsr/Hand2^tm2.1Dsr Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tg(Tbx1-cre)#Dsr/0	involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	MGI:4940095
cn3	Hand2^tm1Dsr/Hand2^tm2.1Dsr Isl1^tm1(cre)Tmj/Isl1⁺	involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:4940090
cn4	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Nkx2-5-cre)9Eno/0	involves: 129 * 129S7/SvEvBrd * C57BL/6	MGI:4940089
cn5	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Mef2c-cre)#Blk/0	involves: 129 * 129S7/SvEvBrd * C57BL/6	MGI:4940093
cn6	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Tbx1-cre)#Dsr/0	involves: 129 * 129S7/SvEvBrd * C57BL/6	MGI:4940094
cn7	Hand2^tm1Dsr/Hand2^tm2.1Dsr Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Isl1^tm1(cre)Tmj/Isl1⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:4940091

Allelic Composition	Hand2^tm2.1Dsr/Hand2^tm2.1Dsr
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:169213 )

• mice are viable and fertile

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tg(Tbx1-cre)#Dsr/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Hand2^tm1Dsr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)
Tg(Tbx1-cre)#Dsr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:169213 )

• at E12.5, mice exhibit narrowed outflow tract and hypoplastic outlet or subpulmonary conus compared with wild-type mice

decreased heart right ventricle size ( J:169213 )

• at E14.5, the right ventricular cavity is smaller than in wild-type mice

• however, the right ventricular muscle wall thickness is normal

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Isl1^tm1(cre)Tmj/Isl1⁺
Genetic Background	involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1Dsr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169213 )

• mice die at E10.5

cardiovascular system

abnormal cardiac outflow tract development ( J:169213 )

• shortened

heart right ventricle hypoplasia ( J:169213 )

• severe

cellular

increased apoptosis ( J:169213 )

• at E9.0, mice exhibit increased apoptosis in the pharyngeal mesoderm compared with wild-type mice

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Nkx2-5-cre)9Eno/0
Genetic Background	involves: 129 * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169213 )

• mice die at E12.5

cardiovascular system

decreased heart left ventricle size ( J:169213 )

• slightly at E9.5

decreased heart right ventricle size ( J:169213 )

• slightly at E9.5

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Mef2c-cre)#Blk/0
Genetic Background	involves: 129 * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169213 )

• mice die at E13.5

cardiovascular system

thin myocardium ( J:169213 )

persistent truncus arteriosus ( J:169213 )

• immature truncus arteriosis

abnormal tricuspid valve morphology ( J:169213 )

• mice lack the anlage of the tricuspid valve between the right atrium and ventricle unlike wild-type mice

ventricular septal defect ( J:169213 )

decreased heart right ventricle size ( J:169213 )

• at E9.5 but not as severely as in Hand2^tm1Dsr homozygotes

heart right ventricle hypoplasia ( J:169213 )

• at E12.5

muscle

thin myocardium ( J:169213 )

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Tbx1-cre)#Dsr/0
Genetic Background	involves: 129 * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:169213 )

• mice die at E15.5

cardiovascular system

abnormal cardiac outflow tract development ( J:169213 )

• shortened at E10.5 and E13.5

decreased heart right ventricle size ( J:169213 )

• at E13.5, but not at E10.5

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Isl1^tm1(cre)Tmj/Isl1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart development ( J:169213 )

• at E9.5, mice exhibit fewer progenitor cells migration into the outflow tract compared with control mice

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