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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igfbp3tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:4888286
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igfbp3tm1Lex/Igfbp3tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:4888297


Genotype
MGI:4888297
hm1
Allelic
Composition
Igfbp3tm1Lex/Igfbp3tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igfbp3tm1Lex mutation (1 available); any Igfbp3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in mice fed a high-fat diet
• mice exhibit increased hepatic glucose turnover at rest compared with wild-type mice
• however, insulin sensitivity under hyperinsulinemic conditions is normal
• at 4 weeks and further at 12 weeks, when fed a high-fat diet
• pre- and post-high-fat diet
• basal concentrations of insulin are increased compared to in wild-type mice
• however, insulin levels are normal after glucose stimulation
• in fasted and fed states
• when fed a high-fat diet, resting metabolic rate is decreased compared to in wild-type mice
• however, the respiratory exchange ratio is normal

muscle
• in fed and fasted states
• in fed and fasted states

growth/size/body
• by weaning until 16 weeks of age and while being fed a high-fat diet
• in a fasted state

behavior/neurological
• at 7 to 10 weeks and 12 weeks of age when fed a high-fat diet

adipose tissue

liver/biliary system
• in a fasted state

limbs/digits/tail
• in fed and fasted states
• in fed and fasted states





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory