Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh14tm1Rsad mutation
(1 available);
any
Myh14 mutation
(81 available)
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normal phenotype
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• mice are viable, appear normal in size and do not display any gross physical or behavioral abnormalities
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nervous system
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N |
• mice exhibit no obvious defects in brain structure
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cardiovascular system
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N |
• mice exhibit no obvious defects in heart development
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respiratory system
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N |
• mice exhibit no obvious defects in lung development
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mortality/aging
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• embryos die as a result of cardiomyopathy after E14.5
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cellular
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• cardiomyocytes show an increase in acetylated tubulin staining suggesting an increase in microtubule stability
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• at E13.5, gamma-tubulin staining showed abnormal formation of multiple centrosomes in mitotic cardiac myocytes
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• cardiomyocytes exhibit impaired karyokinesis and multiple centrosomes
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• mitotic cardiomyocytes lack a bipolar spindle at metaphase; instead, spindles are deformed with irregular aggregated chromosomes
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cardiovascular system
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• at E13.5, 91% of cardiomyocytes exhibit an abnormal shape
• 9% of cardiomyocytes are binucleated
• nuclei are irregular and significantly larger, sometimes exhibiting a multilobed appearance
• mitotic cardiomyocytes lack a bipolar spindle; instead, spindles are deformed with irregular aggregated chromosomes
• however, sarcomere formation is normal in E13.5 cardiac myocytes
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• at E13.5, hearts exhibit a marked reduction in cardiomyocytes
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• embryonic heart is severely hypoplastic; however, numbers of cardiac myocytes are sufficient to support life to E14.5
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muscle
cardiovascular system
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• mice exhibit cardiomyocyte hypertrophy and death, and interstitial fibrosis
• average area of a cardiac myocyte is 4 times larger than control
• intercalated discs are disrupted in cardiac myocytes as determined by N-cadherin staining
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muscle
growth/size/body
Analysis Tools