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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rag2tm1.1Flv
targeted mutation 1.1, Richard A Flavell
MGI:4887836
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac MGI:5296680
cx2
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac MGI:4887951
cx3
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac MGI:4887950
cx4
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:5605181
cx5
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:5605192
cx6
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:5605193
cx7
Il2rgtm1.1Flv/Y
Rag2tm1.1Flv/Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:4887942
cx8
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:5605194
cx9
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:4887944
cx10
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac MGI:4887947


Genotype
MGI:5296680
cx1
Allelic
Composition
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (28 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal total cell content of the bone marrow, frequencies of myeloid cells in the bone marrow, spleen, and peripheral blood, and the frequencies of macrophages in the bone marrow and spleen
• mice produce humanized monocytes/macrophages with augmented functional properties (migration, phagocytosis, activation, and responses to LPS) and production of human cytokines

skeleton
N
• mice exhibit normal bones

craniofacial
N
• mice exhibit normal teeth

hematopoietic system
N
• mice exhibit normal total cell content of the bone marrow, frequencies of myeloid cells in the bone marrow, spleen, and peripheral blood, and the frequencies of macrophages in the bone marrow and spleen




Genotype
MGI:4887951
cx2
Allelic
Composition
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (2 available); any Csf2 mutation (30 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit improved engraftment with CD34+ hematopoietic cells with improved human myeloid cell reconstitution in the lung compared with wild-type mice




Genotype
MGI:4887950
cx3
Allelic
Composition
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (24 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit improved engraftment with CD34+ hematopoietic cells with improved human myeloid cell reconstitution in the lung compared with wild-type mice




Genotype
MGI:5605181
cx4
Allelic
Composition
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (28 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (24 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are higher in engrafted mutant as compared to controls, however, numbers are not as high as in mice that also carry Tg(SIRPA)1Flv
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




Genotype
MGI:5605192
cx5
Allelic
Composition
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (28 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (2 available); any Csf2 mutation (30 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• numbers of myeloid cells in non lymphoid tissues (lung, liver, colon) are incerased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are higher in engrafted mutant as compared to controls, however, numbers are not as high as in mice that also carry Tg(SIRPA)1Flv
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




Genotype
MGI:5605193
cx6
Allelic
Composition
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (28 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (24 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow
• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




Genotype
MGI:4887942
cx7
Allelic
Composition
Il2rgtm1.1Flv/Y
Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice engrafted with human fetal liver hematopoietic and progenitor cells support S. Typhi replication and persistent infection
• mice exhibit engraftment with human fetal liver hematopoietic and progenitor cells to reconstitution a functional human immune system




Genotype
MGI:5605194
cx8
Allelic
Composition
Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (28 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (2 available); any Csf2 mutation (30 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow
• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




Genotype
MGI:4887944
cx9
Allelic
Composition
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice engrafted with human fetal liver hematopoietic and progenitor cells support S. Typhi replication and persistent infection
• mice exhibit engraftment with human fetal liver hematopoietic and progenitor cells to reconstitution a functional human immune system




Genotype
MGI:4887947
cx10
Allelic
Composition
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background
involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (124 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (93 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit increased levels of human engraftment in the bone marrow with improved multilineage differentiation of hematopoietic cells and an increased ratio of myelomonocytic versus lymphoid lineages compared with wild-type mice

hematopoietic system
• in engrafted and non-engrafted mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory