About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Dkk3-cre)D9Tfur
transgene insertion D9, Takahisa Furukawa
MGI:4881674
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Dkk3-cre)D9Tfur/0
Top2btm2Jcw/Top2btm2Jcw 		involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:6382623
cn2
 		Prdm13tm1.1Tfur/Prdm13tm1.1Tfur
Tg(Dkk3-cre)D9Tfur/0 		involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N MGI:5780207


Genotype
MGI:6382623
cn1
Allelic
Composition		 Tg(Dkk3-cre)D9Tfur/0
Top2btm2Jcw/Top2btm2Jcw
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dkk3-cre)D9Tfur mutation (2 available)
Top2btm2Jcw mutation (1 available); any Top2b mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal photoreceptor outer segment morphology ( J:282250 )
• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS
photoreceptor outer segment degeneration ( J:282250 )
• virtually no OS by age P14
abnormal retina cone cell morphology ( J:282250 )
• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina cone cell outer segment morphology ( J:282250 )
• shorter neural processes on s-cones at age P0
• no neural processes on s-cones at age P7 and P14
abnormal retina rod cell morphology ( J:282250 )
• outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina rod cell outer segment morphology ( J:282250 )
• elimination or significant reduction of rhodopsin signal at age P7 and P14
retina photoreceptor degeneration ( J:282250 )
• increased apoptosis in outer nuclear layer at age P7, P14 and P21
abnormal retina pigment epithelium morphology ( J:282250 )
• retina detached from RPE at age P14 and P21 owing to absence of outer segment
thin retina outer nuclear layer ( J:282250 )
• at age P7 and P14
abnormal retina outer plexiform layer morphology ( J:282250 )
• absent at age P7, P14 and P21
abnormal retina outer limiting membrane morphology ( J:282250 )
• elimination or significant reduction of rhodopsin signal at age P7 and P14

nervous system
abnormal photoreceptor outer segment morphology ( J:282250 )
• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS
photoreceptor outer segment degeneration ( J:282250 )
• virtually no OS by age P14
abnormal retina cone cell morphology ( J:282250 )
• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina cone cell outer segment morphology ( J:282250 )
• shorter neural processes on s-cones at age P0
• no neural processes on s-cones at age P7 and P14
abnormal retina rod cell morphology ( J:282250 )
• outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina rod cell outer segment morphology ( J:282250 )
• elimination or significant reduction of rhodopsin signal at age P7 and P14
retina photoreceptor degeneration ( J:282250 )
• increased apoptosis in outer nuclear layer at age P7, P14 and P21

pigmentation
abnormal retina pigment epithelium morphology ( J:282250 )
• retina detached from RPE at age P14 and P21 owing to absence of outer segment




Genotype
MGI:5780207
cn2
Allelic
Composition		 Prdm13tm1.1Tfur/Prdm13tm1.1Tfur
Tg(Dkk3-cre)D9Tfur/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm13tm1.1Tfur mutation (1 available); any Prdm13 mutation (45 available)
Tg(Dkk3-cre)D9Tfur mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased amacrine cell number ( J:222242 )
• specific reduction in the number of GABAergic or glycinergic amacrine cells at P14
abnormal retina inner plexiform layer morphology ( J:222242 )
• loss of the S2/S3 border neurite bundle labeled by anti-Calretinin antibodies in the IPL at P14

behavior/neurological
abnormal optokinetic reflex ( J:222242 )
• at 2 months of age, mice exhibit higher responses to visual stimuli in initial optokinetic responses with a broader range of spatial and temporal frequencies than those observed in controls

nervous system
decreased amacrine cell number ( J:222242 )
• specific reduction in the number of GABAergic or glycinergic amacrine cells at P14




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory