Phenotypes associated with this allele

• Allele Symbol: Itpr3^{tm1(NCOM)Mfgc}
• Allele Name: targeted mutation 1, Mammalian Functional Genomics Centre
• Allele ID: MGI:4880235
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itpr3^tm1(NCOM)Mfgc/Itpr3^tm1(NCOM)Mfgc	involves: C57BL/6J * C57BL/6N	MGI:5532681

Genotype
MGI:5532681

hm1

• Allelic Composition: Itpr3^{tm1(NCOM)Mfgc}/Itpr3^{tm1(NCOM)Mfgc}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: N01293P1_C_239W_C5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased fluid intake ( J:201643 )

abnormal liquid preference ( J:201643 )

• in a 96 h two-bottle choice test, mice exhibit an increased preference for bottles with calcium chloride, calcium lactate, magnesium chloride, ammonium chloride and quinine hydrochloride compared to wild-type mice

• in a 96 h two-bottle choice test, mice preferred calcium chloride and calcium lactate to water unlike wild-type mice

• in a 96 h two-bottle choice test, mice exhibit reduced preference for saccharin compared with wild-type mice

• in a 96 h two-bottle choice test, mice exhibit a higher preference for denatonium, quinine hydrochloride, calcium chloride, calcium lactate, magnesium chloride and ammonium chloride compared with wild-type mice

• in a 96 h two-bottle choice test, mice exhibit a lower preference for saccharin, sucrose, maltose, polycose, monosodium glutamate, inosine monophosphate, trisodium pyrophosphate, zinc chloride, and potassium chloride compared with wild-type mice

low sweet preference ( J:201643 )

• in a 96 h two-bottle choice test, mice exhibit reduced preference for saccharin compared with wild-type mice

• in a 96 h two-bottle choice test, mice exhibit a lower preference for saccharin, sucrose, maltose and polycose compared with wild-type mice

taste/olfaction

abnormal gustatory system physiology ( J:201643 )

• in a 96 h two-bottle choice test, mice exhibit an increased preference for bottles with calcium chloride, calcium lactate, magnesium chloride, ammonium chloride and quinine hydrochloride compared to wild-type mice

• in a 96 h two-bottle choice test, mice preferred calcium chloride and calcium lactate to water unlike wild-type mice

• in a 96 h two-bottle choice test, mice exhibit reduced preference for saccharin compared with wild-type mice

• in a 96 h two-bottle choice test, mice exhibit a higher preference for denatonium, quinine hydrochloride, calcium chloride, calcium lactate, magnesium chloride and ammonium chloride compared with wild-type mice

• in a 96 h two-bottle choice test, mice exhibit a lower preference for saccharin, sucrose, maltose, polycose, monosodium glutamate, inosine monophosphate, trisodium pyrophosphate, zinc chloride, and potassium chloride compared with wild-type mice