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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcr4tm3.1Yzo
targeted mutation 3.1, Yong-Rui Zou
MGI:4878934
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo Not Specified MGI:4878989
cn2
 		Cxcr4tm2Yzo/Cxcr4tm3.1Yzo
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd MGI:4878990


Genotype
MGI:4878989
hm1
Allelic
Composition		 Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm3.1Yzo mutation (0 available); any Cxcr4 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:167314 )
• mice are present in Mendelian ratios until E18.5

immune system
impaired myelopoiesis ( J:167314 )
• in the bone marrow
abnormal B cell physiology ( J:167314 )
• pro-B cells exhibit impaired chemotactic response towards CXCL12 compared with wild-type cells
• however, CXCL12-stimulated VCAM1 binding is normal

cardiovascular system
abnormal blood vessel morphology ( J:167314 )
• mice lack large vessels in the gastrointestinal area compared with wild-type mice

nervous system
abnormal cerebellum external granule cell layer morphology ( J:167314 )
• mice exhibit displaced cells of the external granule layer in the cerebellum compared with wild-type mice

hematopoietic system
impaired myelopoiesis ( J:167314 )
• in the bone marrow
abnormal B cell physiology ( J:167314 )
• pro-B cells exhibit impaired chemotactic response towards CXCL12 compared with wild-type cells
• however, CXCL12-stimulated VCAM1 binding is normal




Genotype
MGI:4878990
cn2
Allelic
Composition		 Cxcr4tm2Yzo/Cxcr4tm3.1Yzo
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Cxcr4tm2Yzo mutation (1 available); any Cxcr4 mutation (40 available)
Cxcr4tm3.1Yzo mutation (0 available); any Cxcr4 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:167314 )
• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes

immune system
abnormal B cell differentiation ( J:167314 )
• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory