All Phenotypes Fto<tm1.1Pzg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fto^tm1.1Pzg
targeted mutation 1.1, Pumin Zhang
MGI:4868738

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fto^tm1.1Pzg/Fto^tm1.1Pzg Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL	MGI:4868751

Allelic Composition	Fto^tm1.1Pzg/Fto^tm1.1Pzg Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fto^tm1.1Pzg mutation (1 available); any Fto mutation (71 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased lean body mass ( J:166984 )

decreased body length ( J:166984 )

postnatal growth retardation ( J:166984 )

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:166984 )

abnormal carbon dioxide production ( J:166984 )

• relative to lean mass, mice exhibit increased oxygen consumption and carbon dioxide production compared with wild-type mice

abnormal oxygen consumption ( J:166984 )

• relative to lean mass, mice exhibit increased oxygen consumption and carbon dioxide production compared with wild-type mice

behavior/neurological

abnormal eating behavior ( J:166984 )

• when normalized to lean mass

skeleton

decreased bone mineral density ( J:166984 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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