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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spdeftm1Shiv
targeted mutation 1, Ramesh Shivdasani
MGI:4867866
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spdeftm1Shiv/Spdeftm1Shiv involves: 129S4/SvJae MGI:4867867


Genotype
MGI:4867867
hm1
Allelic
Composition
Spdeftm1Shiv/Spdeftm1Shiv
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spdeftm1Shiv mutation (0 available); any Spdef mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Polypoid antral hyperplasia in Spdeftm1Shiv/Spdeftm1Shiv mice

mortality/aging
• viable at birth but born in slightly reduced numbers

digestive/alimentary system
• profound thickening of the antral stomach at 4 months of age or older
• 50% of mice develop polypoid hyperplasia of the antrum within 1.5 years of life
• antral secretory granules are reduced in mucous gland cells
• expanded zone of proliferating epithelial cells
• dilated, elongated, and tortuous foveolae
• leukocyte infiltrates sometimes seen in the duodenal submucosa
• moderate to severe antral inflammation in 90% of mice by 4 months of age
• inflammation always present when antral hyperplasia is present
• formation of submucosal lymphoid follicles sometimes in older animals
• inflammation usually absent in gastric corpus when antral hyperplasia is absent

immune system
• leukocyte infiltrates sometimes seen in the duodenal submucosa
• moderate to severe antral inflammation in 90% of mice by 4 months of age
• inflammation always present when antral hyperplasia is present
• formation of submucosal lymphoid follicles sometimes in older animals
• inflammation usually absent in gastric corpus when antral hyperplasia is absent





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory