All Phenotypes Fbxw7<tm1.1Axbe> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Notch1^tm1Agt/Notch1⁺ Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL	MGI:4867645
cn2	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0	involves: 129P2/OlaHsd	MGI:5293752
cn3	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm2.1Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5293753
cn4	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4867644
cn5	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:4867643
cn6	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj/0	Not Specified	MGI:5293751

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Notch1^tm1Agt/Notch1⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7^tm1.1Axbe mutation (2 available); any Fbxw7 mutation (82 available)
Notch1^tm1Agt mutation (0 available); any Notch1 mutation (115 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:166928 )

• the number of Map+ cells that differentiate in culture is increased while the number of Nes+ cells is decreased compared to in cultures from wild-type mice

cellular

abnormal neuron differentiation ( J:166928 )

• the number of Map+ cells that differentiate in culture is increased while the number of Nes+ cells is decreased compared to in cultures from wild-type mice

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7^tm1.1Axbe mutation (2 available); any Fbxw7 mutation (82 available)
Jun^tm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(En2-cre)22Alj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell morphology ( J:176598 )

• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj mice

• however, Purkinje cell density is rescued

abnormal cerebellum fissure morphology ( J:176598 )

• supranumeral fissures

small cerebellum ( J:176598 )

• partially rescued compared with Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj mice

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm2.1Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7^tm1.1Axbe mutation (2 available); any Fbxw7 mutation (82 available)
Jun^tm2.1Wag mutation (0 available); any Jun mutation (12 available)
Jun^tm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(En2-cre)22Alj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell morphology ( J:176598 )

• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj mice

• however, Purkinje cell density is rescued

small cerebellum ( J:176598 )

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron apoptosis ( J:166928 )

• neurosphere apoptosis is decreased compared to in Fbxw7^tm1Axbe/Fbxw7^tm1Axbe Tg(Nes-cre)1Kln mice

abnormal tectum morphology ( J:166928 )

• the cellularity defect in the mantle layer of the midbrain tectum observed in Fbxw7^tm1Axbe/Fbxw7^tm1Axbe Tg(Nes-cre)1Kln mice is rescued

• the number of stem cells in the tectal ventricular zone is increased compared to in wild-type mice

cellular

abnormal neuron apoptosis ( J:166928 )

• neurosphere apoptosis is decreased compared to in Fbxw7^tm1Axbe/Fbxw7^tm1Axbe Tg(Nes-cre)1Kln mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:166928 )

nervous system

nervous system phenotype ( J:166928 )

N	• mice exhibit normal gliogenesis

abnormal neuron differentiation ( J:166928 )

• the number of neuroblasts in the cortex is reduced compared to in wild-type mice

• at E16.5, neuron progenitor apoptosis in the tectal mantle layer is increased compared to in wild-type mice

• neurosphere apoptosis is increased compared to in wild-type mice

• differentiation of neurospheres in culture is blocked compared to cultured wild-type cells

abnormal brain development ( J:166928 )

• mice exhibit a reduction in the number of cells in regions of the brain occupied by committed progenitors and differentiated cells compared with wild-type mice

• areas containing immature cells exhibit normal or increased numbers of cells compared to in wild-type mice

abnormal cortical intermediate zone morphology ( J:166928 )

• the intermediate zone contains fewer cells than in wild-type mice

abnormal cortical plate morphology ( J:166928 )

• the cortical plate contains fewer cells than in wild-type mice

abnormal cerebellum development ( J:166928 )

• the cerebellar anlage contains fewer cells than in wild-type mice

abnormal tectum morphology ( J:166928 )

• the midbrain tectum, especially the tectal mantle, contains fewer cells than in wild-type mice

• the number of cells in the tectal ventricular zone is increased compared to in wild-type mice

thalamus hypoplasia ( J:166928 )

• the thalamus contains fewer cells than in wild-type mice

abnormal cerebral cortex morphology ( J:166928 )

• the forebrain cortex contains fewer cells than in wild-type mice

abnormal embryonic/fetal subventricular zone morphology ( J:166928 )

• the cortical subventricular zone contains fewer cells than in wild-type mice

decreased neuronal precursor cell number ( J:166928 )

• smaller and fewer without a defect in proliferation

cellular

abnormal neuron differentiation ( J:166928 )

• the number of neuroblasts in the cortex is reduced compared to in wild-type mice

• at E16.5, neuron progenitor apoptosis in the tectal mantle layer is increased compared to in wild-type mice

• neurosphere apoptosis is increased compared to in wild-type mice

• differentiation of neurospheres in culture is blocked compared to cultured wild-type cells

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7^tm1.1Axbe mutation (2 available); any Fbxw7 mutation (82 available)
Tg(En2-cre)22Alj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:176598 )

N	• molecular layer structure is normal

abnormal neuron differentiation ( J:176598 )

• at E18.5, granule cell progenitors exhibit premature migration compared to in wild-type mice

abnormal cerebellar foliation ( J:176598 )

abnormal Purkinje cell morphology ( J:176598 )

• Purkinje cells are small, irregularly-shaped, less organized, more widely spread, and defective in arborization compared to in wild-type mice

decreased Purkinje cell number ( J:176598 )

• between P2, P7 and in the adult

decreased Purkinje cell size ( J:176598 )

abnormal cerebellum fissure morphology ( J:176598 )

• supranumeral fissures in the central lobes

cerebellum vermis hypoplasia ( J:176598 )

small cerebellum ( J:176598 )

• as early as P2

cellular

abnormal neuron differentiation ( J:176598 )

• at E18.5, granule cell progenitors exhibit premature migration compared to in wild-type mice

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