Phenotypes associated with this allele

• Allele Symbol: Gsk3b^tm1.2Ypc
• Allele Name: targeted mutation 1.2, YiPing Chen
• Allele ID: MGI:4867289
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsk3b^tm1.2Ypc/Gsk3b^tm1.2Ypc	involves: 129S4/SvJaeSor * C57BL/6 * CBA	MGI:4867290

Genotype
MGI:4867290

hm1

• Allelic Composition: Gsk3b^tm1.2Ypc/Gsk3b^tm1.2Ypc
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:166721 )

• die within 24 hrs of birth

craniofacial

abnormal palate development ( J:166721 )

• at E12.5 cell proliferation is enhanced in the palate epithelium but at E13.5 proliferation is decreased and apoptosis is increased in the palate epithelium

failure of palatal shelf elevation ( J:166721 )

• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

palatal shelves fail to meet at midline ( J:166721 )

• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation

complete cleft palate ( J:166721 )

• complete cleft palate

digestive/alimentary system

abnormal palate development ( J:166721 )

• at E12.5 cell proliferation is enhanced in the palate epithelium but at E13.5 proliferation is decreased and apoptosis is increased in the palate epithelium

failure of palatal shelf elevation ( J:166721 )

• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

palatal shelves fail to meet at midline ( J:166721 )

• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation

complete cleft palate ( J:166721 )

• complete cleft palate

growth/size/body

abnormal palate development ( J:166721 )

• at E12.5 cell proliferation is enhanced in the palate epithelium but at E13.5 proliferation is decreased and apoptosis is increased in the palate epithelium

failure of palatal shelf elevation ( J:166721 )

• at E14.5 the shelves remain in the vertical position and fail to elevate to the position above the tongue

palatal shelves fail to meet at midline ( J:166721 )

• at E18.5 anterior shelves are in a horizontal position but fail to meet at the midline; posterior shelves remain in a vertical orientation

complete cleft palate ( J:166721 )

• complete cleft palate