Phenotypes associated with this allele

• Allele Symbol: Hadh^tm1Csta
• Allele Name: targeted mutation 1, Charles A Stanley
• Allele ID: MGI:4867189
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hadh^tm1Csta/Hadh^tm1Csta	involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss	MGI:4867217

Genotype
MGI:4867217

hm1

• Allelic Composition: Hadh^tm1Csta/Hadh^tm1Csta
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal distribution of alpha-cells throughout the islet in Hadh^tm1Csta/Hadh^tm1Csta mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:166803 )

• higher insulin/glucose ratios in fasted mice

• insulin sensitivity is normal

decreased circulating glucose level ( J:166803 )

• lower basal glucose after 2 hours of fasting

• lower glucose in response to oral amino acid administration to mice fasted 2 hours

• lower glucose after 24 hour fast

• normal response in a glucose tolerance test

increased circulating insulin level ( J:166803 )

• elevated basal insulin after 2 hours of fasting

• elevated insulin in response to oral amino acid administration to mice fasted 2 hours

• insulin responses are also normal in a glucose tolerance test even though insulin levels are elevated

• increased insulin response to amino acid administration, particularly glutamine, leucine, and alanine

abnormal fatty acids level ( J:166803 )

• plasma 3-OH-butyrylcarnitine is elevated 4X in the fed state and 2X after 24 hours of fasting

increased fatty acids level ( J:166803 )

• 6 carbon fatty acid levels are increased 3X after 24 hours of fasting

• 8 carbon fatty acid levels are increased 2X after 24 hours of fasting

aciduria ( J:166803 )

• increased urine secretion of 3-hydroxyglutarate

• increased urine secretion of glutaconic acid

endocrine/exocrine glands

abnormal pancreatic alpha cell morphology ( J:166803 )

• glucagon staining alpha cells are distributed throughout the islets rather than being restricted to the outer margin

• glucagon content of the islets is normal

renal/urinary system

aciduria ( J:166803 )

• increased urine secretion of 3-hydroxyglutarate

• increased urine secretion of glutaconic acid