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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-TNFSF13)3919Mhah
transgene insertion 3919, Michael Hahne
MGI:4850020
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Lck-TNFSF13)3919Mhah/0 B6.Cg-Tg(Lck-TNFSF13)3919Mhah MGI:4850030


Genotype
MGI:4850030
tg1
Allelic
Composition
Tg(Lck-TNFSF13)3919Mhah/0
Genetic
Background
B6.Cg-Tg(Lck-TNFSF13)3919Mhah
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in older mice with incidence increasing with age

immune system
• survival of cultured B-1 B cells is increased 3-fold compared with wild-type cells
• survival of cultured B-1 B cells treated with death agonists (VP-16, doxorubicin, and staurosporin) is increased compared with similarly treated wild-type cells
• in the mesenteric lymph node
• in the mesenteric lymph node
• in the mesenteric lymph node
• in 40% of mice at 9 to 12 months
• older mice exhibit highly disorganized spleen architecture compared with wild-type mice
• in older mice with incidence increasing with age
• due to increased cell number that increases in incidence and severity over time
• the percentage of B220+ cells increase slightly while the percentage of CD8+ T cells is slightly decreased in the mesenteric lymph node compared to in wild-type mice
• enlarged blast-like B and T cells accumulate in the mesenteric lymph nodes unlike in wild-type mice
• due to increased cell number that increases in incidence and severity over time

neoplasm
• at 9 to 12 months, mice exhibit lymphoid tumors due to expansion of peritoneal B-1 B cell populations with infiltration into nonlymphoid tissues (lungs and kidneys)

hematopoietic system
• survival of cultured B-1 B cells is increased 3-fold compared with wild-type cells
• survival of cultured B-1 B cells treated with death agonists (VP-16, doxorubicin, and staurosporin) is increased compared with similarly treated wild-type cells
• in the mesenteric lymph node
• in the mesenteric lymph node
• in the mesenteric lymph node
• older mice exhibit highly disorganized spleen architecture compared with wild-type mice
• in older mice with incidence increasing with age

cellular
• survival of cultured B-1 B cells is increased 3-fold compared with wild-type cells
• survival of cultured B-1 B cells treated with death agonists (VP-16, doxorubicin, and staurosporin) is increased compared with similarly treated wild-type cells





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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory