Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcqtm1Litt mutation
(3 available);
any
Prkcq mutation
(51 available)
Tg(Lck-Notch3)#Issc mutation
(0 available)
|
|
|
mortality/aging
|
|
• compared with Tg(lck-Notch3)#Issc mice
|
|
|
• 35% of mice die prior to 20 weeks of age
• of mice that survive beyond 20 weeks, 50% die over 30 weeks of age and 20% survive at 50 weeks of age
|
neoplasm
|
|
• 40% of mice that survive beyond 20 weeks of age exhibit lymphoproliferative disease (enlarged upper mediastium and 2- to 3-fold increase in spleen size and weight) compared with 95% of Tg(lck-Notch3)#Issc mice
|
immune system
|
|
• 2- to 3-fold in 40% of mice that survive beyond 20 weeks of age
|
|
|
• 2- to 3-fold in 40% of mice that survive beyond 20 weeks of age
|
growth/size/body
|
|
• 40% of mice that survive beyond 20 weeks of age exhibit enlarged upper mediastium compared with wild-type mice
|
|
|
• 2- to 3-fold in 40% of mice that survive beyond 20 weeks of age
|
|
|
• 2- to 3-fold in 40% of mice that survive beyond 20 weeks of age
|
hematopoietic system
|
|
• 2- to 3-fold in 40% of mice that survive beyond 20 weeks of age
|
|
|
• 2- to 3-fold in 40% of mice that survive beyond 20 weeks of age
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
mortality/aging
|
|
• 80% die between 10-12 weeks of age and by 16 weeks of age, 95% die
(J:63300)
• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
(J:96010)
|
neoplasm
|
|
• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
|
|
|
• thymus, spleen, and lymph nodes show massive infiltration by a monotonous lymphoblastic cell population
• mutants develop aggressive multicentric T-cell lymphomas showing features of lymphoblastic lymphoma with high penetrance by 7 weeks of age
• tumors sustain characteristics of immature thymocytes, including expression of CD25, pTalpha, and activated NF-kappaB
|
|
|
• tumor cell infiltration is seen in the liver, lungs, kidney, bone marrow and peripheral blood, indicating leukemic phase of the disease
|
behavior/neurological
immune system
|
|
• hyperplastic thymus is seen in some mutants at 5-6 weeks of age
|
|
|
• in 3 week old mutants, particularly the late double negative cells
|
|
|
• 5- to 6-fold increase in size and weight of spleen at 5-6 weeks of age
|
|
|
• disruption of thymocyte differentiation; all thymocyte subsets express high levels of CD25 and are broadly distributed in the cortex and medulla of the thymus, indicating a failure to downregulate CD25 expression the occurs normally in double positive and single positive subsets after 17-18 dpc
|
|
|
• 5- to 6-fold increase in size and weight of peripheral (axillary, cervical, and abdominal) lymph nodes at 5-6 weeks of age
|
hematopoietic system
|
|
• hyperplastic thymus is seen in some mutants at 5-6 weeks of age
|
|
|
• in 3 week old mutants, particularly the late double negative cells
|
|
|
• 5- to 6-fold increase in size and weight of spleen at 5-6 weeks of age
|
|
|
• disruption of thymocyte differentiation; all thymocyte subsets express high levels of CD25 and are broadly distributed in the cortex and medulla of the thymus, indicating a failure to downregulate CD25 expression the occurs normally in double positive and single positive subsets after 17-18 dpc
|
endocrine/exocrine glands
|
|
• hyperplastic thymus is seen in some mutants at 5-6 weeks of age
|
|
|
• in 3 week old mutants, particularly the late double negative cells
|
|
|
• 95% of mice die by 16 weeks of age with multicentric T-cell lymphomas
|
|
|
• thymus, spleen, and lymph nodes show massive infiltration by a monotonous lymphoblastic cell population
• mutants develop aggressive multicentric T-cell lymphomas showing features of lymphoblastic lymphoma with high penetrance by 7 weeks of age
• tumors sustain characteristics of immature thymocytes, including expression of CD25, pTalpha, and activated NF-kappaB
|
growth/size/body
|
|
• 5- to 6-fold increase in size and weight of spleen at 5-6 weeks of age
|
Analysis Tools