About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPSw)10Jiri
transgene insertion 10, Jill C Richardson
MGI:4843212
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0
B6.Cg-Tg(Thy1-APPSw)10Jiri Tg(Thy1-PSEN1*M146V)#Jiri MGI:5646215
cx2
Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0
involves: C3H * C57BL/6 MGI:5646171
tg3
Tg(Thy1-APPSw)10Jiri/0 involves: C3H * C57BL/6 MGI:4843219


Genotype
MGI:5646215
cx1
Allelic
Composition
Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSw)10Jiri Tg(Thy1-PSEN1*M146V)#Jiri
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• marked amyloidosis in the thalamus, hippocampal formation and cerebral cortex (J:156577)
• marked amyloidosis in the thalamus, hippocampal formation and cerebral cortex (J:156577)
• amyloid beta deposition that appears first at about 3-4 months of age (J:156577)
• amyloid beta deposition that appears first at about 3-4 months of age (J:156577)

nervous system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited (J:156577)
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited (J:156577)
• amyloid beta deposition that appears first at about 3-4 months of age (J:156577)
• amyloid beta deposition that appears first at about 3-4 months of age (J:156577)
• the brain and its component regions grow more than in wild-type mice from 6-14 months of age (5.1% vs 2.8% in wild-type), showing an increase in volume and size over time; this may be due to the progressive amyloid deposition and astrogliosis (J:156577)
• thalamus, cerebellum, cerebral cortex, and caudoputamen are proportionally larger from an early age in mutants than in wild-type mice but they show a relative decline with age (J:156577)
• thalamus and caudoputamen decline in relative volume faster than in wild-type mice, although cerebral cortex declines less rapidly (J:156577)
• corpus callosum, corticospinal tract, hypothalamus, midbrain-hindbrain and fornix system account for a smaller proportion of the brain, although they progressively enlarge with age similarly to wild-type mice (J:156577)
• the brain and its component regions grow more than in wild-type mice from 6-14 months of age (5.1% vs 2.8% in wild-type), showing an increase in volume and size over time; this may be due to the progressive amyloid deposition and astrogliosis (J:156577)
• thalamus, cerebellum, cerebral cortex, and caudoputamen are proportionally larger from an early age in mutants than in wild-type mice but they show a relative decline with age (J:156577)
• thalamus and caudoputamen decline in relative volume faster than in wild-type mice, although cerebral cortex declines less rapidly (J:156577)
• corpus callosum, corticospinal tract, hypothalamus, midbrain-hindbrain and fornix system account for a smaller proportion of the brain, although they progressively enlarge with age similarly to wild-type mice (J:156577)
• corpus callosum makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age (J:156577)
• corpus callosum makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age (J:156577)
• decrease in caudoputamen size over time (-2.8% vs. 0.1% in wild-type), even though the caudoputamen is proportionally larger at an early age in mutants than in wild-type mice (J:156577)
• decrease in caudoputamen size over time (-2.8% vs. 0.1% in wild-type), even though the caudoputamen is proportionally larger at an early age in mutants than in wild-type mice (J:156577)
• the hypothalamus makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age (J:156577)
• the hypothalamus makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age (J:156577)
• thalamus is larger in mutants at an early age compared to wild-type mice, however the thalamus declines in relative volume faster than in wild-type mice with age (J:156577)
• thalamus is larger in mutants at an early age compared to wild-type mice, however the thalamus declines in relative volume faster than in wild-type mice with age (J:156577)
• hippocampal formation size is increased by about 11% over 8 months compared to about 0.3% in wild-type mice (J:156577)
• hippocampal formation size is increased by about 11% over 8 months compared to about 0.3% in wild-type mice (J:156577)
• a 2.4% increase in cerebral cortex size compared to a -0.4% decrease in wild-type mice over time (J:156577)
• a 2.4% increase in cerebral cortex size compared to a -0.4% decrease in wild-type mice over time (J:156577)
• cerebellum is larger in mutants at an early age compared to wild-type mice, however a decline in size is seen with age as in wild-type mice (J:156577)
• cerebellum is larger in mutants at an early age compared to wild-type mice, however a decline in size is seen with age as in wild-type mice (J:156577)
• astrogliosis in the cerebral cortex, thalamus, and hippocampal formation at 9-14 months of age (J:156577)
• astrogliosis in the cerebral cortex, thalamus, and hippocampal formation at 9-14 months of age (J:156577)
• the corticospinal tract makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age (J:156577)
• the corticospinal tract makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age (J:156577)

hematopoietic system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited (J:156577)
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited (J:156577)

immune system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited (J:156577)
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited (J:156577)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:156577




Genotype
MGI:5646171
cx2
Allelic
Composition
Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the object recognition test, mice exhibit lower recognition indices than wild-type mice at 6, 8, and 10 months of age, but not at 3 or 4 months of age (J:91273)
• in the object recognition test, mice exhibit lower recognition indices than wild-type mice at 6, 8, and 10 months of age, but not at 3 or 4 months of age (J:91273)

homeostasis/metabolism
• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)
• amyloid beta load is greater in females than males (J:91273)
• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)
• amyloid beta deposits are seen in the cerebrovasculature (J:91273)
• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)
• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)
• amyloid beta load is greater in females than males (J:91273)
• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)
• amyloid beta deposits are seen in the cerebrovasculature (J:91273)
• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)

nervous system
• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)
• amyloid beta load is greater in females than males (J:91273)
• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)
• amyloid beta deposits are seen in the cerebrovasculature (J:91273)
• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)
• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)
• amyloid beta load is greater in females than males (J:91273)
• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)
• amyloid beta deposits are seen in the cerebrovasculature (J:91273)
• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)
• cortical plaques are surrounded by clusters of dystrophic neurites (J:91273)
• cortical plaques are surrounded by clusters of dystrophic neurites (J:91273)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:222897




Genotype
MGI:4843219
tg3
Allelic
Composition
Tg(Thy1-APPSw)10Jiri/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increases with age (J:128647)
• increases with age (J:128647)
• the upper arm dentate gyrus exhibits a smaller number of total neurons compared to in wild-type mice (J:128647)
• the upper arm dentate gyrus exhibits a smaller number of total neurons compared to in wild-type mice (J:128647)
• at 12 months, mice exhibit dystrophic neurites unlike wild-type mice (J:128647)
• at 12 months, mice exhibit dystrophic neurites unlike wild-type mice (J:128647)
• at 12 months, mice exhibit an increase in synapse density compared to in wild-type mice (J:128647)
• the synapse to neuron ration increases between 6 and 12 months, declines slightly at 18 months, and falls markedly at 24 months compared to in wild-type mice (J:128647)
• however, synapse density at 18 and 24 months is normal (J:128647)
• at 12 months, mice exhibit an increase in synapse density compared to in wild-type mice (J:128647)
• the synapse to neuron ration increases between 6 and 12 months, declines slightly at 18 months, and falls markedly at 24 months compared to in wild-type mice (J:128647)
• however, synapse density at 18 and 24 months is normal (J:128647)

behavior/neurological
• at 12 and 18 months, mice exhibit progressive impairment in a Y-maze (a measure of spontaneous alternation behavior) compared with wild-type mice (J:128647)
• however, performance at 2 and 6 months is normal (J:128647)
• at 12 and 18 months, mice exhibit progressive impairment in a Y-maze (a measure of spontaneous alternation behavior) compared with wild-type mice (J:128647)
• however, performance at 2 and 6 months is normal (J:128647)
• at 6, 12, 18, and 24 months but not at 2 months (J:128647)
• at 6, 12, 18, and 24 months but not at 2 months (J:128647)

immune system

hematopoietic system

homeostasis/metabolism
• increases with age (J:128647)
• increases with age (J:128647)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:128647





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory