Mouse Genome Informatics
cx1
    Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0

B6.Cg-Tg(Thy1-APPSw)10Jiri Tg(Thy1-PSEN1*M146V)#Jiri
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• marked amyloidosis in the thalamus, hippocampal formation and cerebral cortex
• amyloid beta deposition that appears first at about 3-4 months of age

nervous system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited
• amyloid beta deposition that appears first at about 3-4 months of age
• the brain and its component regions grow more than in wild-type mice from 6-14 months of age (5.1% vs 2.8% in wild-type), showing an increase in volume and size over time; this may be due to the progressive amyloid deposition and astrogliosis
• thalamus, cerebellum, cerebral cortex, and caudoputamen are proportionally larger from an early age in mutants than in wild-type mice but they show a relative decline with age
• thalamus and caudoputamen decline in relative volume faster than in wild-type mice, although cerebral cortex declines less rapidly
• corpus callosum, corticospinal tract, hypothalamus, midbrain-hindbrain and fornix system account for a smaller proportion of the brain, although they progressively enlarge with age similarly to wild-type mice
• corpus callosum makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
• decrease in caudoputamen size over time (-2.8% vs. 0.1% in wild-type), even though the caudoputamen is proportionally larger at an early age in mutants than in wild-type mice
• the hypothalamus makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age
• thalamus is larger in mutants at an early age compared to wild-type mice, however the thalamus declines in relative volume faster than in wild-type mice with age
• hippocampal formation size is increased by about 11% over 8 months compared to about 0.3% in wild-type mice
• a 2.4% increase in cerebral cortex size compared to a -0.4% decrease in wild-type mice over time
• cerebellum is larger in mutants at an early age compared to wild-type mice, however a decline in size is seen with age as in wild-type mice
• astrogliosis in the cerebral cortex, thalamus, and hippocampal formation at 9-14 months of age
• the corticospinal tract makes up a smaller proportion of the brain than in wild-type mice, however it progressively enlarges with age

hematopoietic system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

immune system
• stellate microgliosis appears from about 5-6 months of age where plaque is increasingly deposited

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:156577


Mouse Genome Informatics
cx2
    Tg(Thy1-APPSw)10Jiri/0
Tg(Thy1-PSEN1*M146V)#Jiri/0

involves: C3H * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the object recognition test, mice exhibit lower recognition indices than wild-type mice at 6, 8, and 10 months of age, but not at 3 or 4 months of age

homeostasis/metabolism
• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)
• amyloid beta load is greater in females than males (J:91273)
• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)
• amyloid beta deposits are seen in the cerebrovasculature (J:91273)
• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)

nervous system
• amyloid beta deposits are first seen in the brain at 3 months of age (J:91273)
• amyloid beta load is greater in females than males (J:91273)
• all mice exhibit cerebral amyloid beta deposits at 4 months of age with levels increasing significantly between 6 and 10 months of age (J:91273)
• amyloid beta deposits are seen in the cerebrovasculature (J:91273)
• extracellular fibrillar amyloid beta plaques are seen in the cerebral cortex from 6 months of age, most prevalent in the infragranular layers, and density increases with age (J:91273)
• cortical plaques are surrounded by clusters of dystrophic neurites

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:222897


Mouse Genome Informatics
tg3
    Tg(Thy1-APPSw)10Jiri/0
involves: C3H * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increases with age
• the upper arm dentate gyrus exhibits a smaller number of total neurons compared to in wild-type mice
• at 12 months, mice exhibit dystrophic neurites unlike wild-type mice
• at 12 months, mice exhibit an increase in synapse density compared to in wild-type mice
• the synapse to neuron ration increases between 6 and 12 months, declines slightly at 18 months, and falls markedly at 24 months compared to in wild-type mice
• however, synapse density at 18 and 24 months is normal

behavior/neurological
• at 12 and 18 months, mice exhibit progressive impairment in a Y-maze (a measure of spontaneous alternation behavior) compared with wild-type mice
• however, performance at 2 and 6 months is normal
• at 6, 12, 18, and 24 months but not at 2 months

immune system

hematopoietic system

homeostasis/metabolism
• increases with age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:128647