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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pcid2tm1Imku
targeted mutation 1, Nobuo Sakaguchi
MGI:4843141
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pcid2tm1Imku/Pcid2tm1Imku
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4843145


Genotype
MGI:4843145
cn1
Allelic
Composition
Pcid2tm1Imku/Pcid2tm1Imku
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Pcid2tm1Imku mutation (0 available); any Pcid2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• severely reduced numbers of splenic B cells in the T1(Cd21loCd24hi) and T2 (Cd21hiCd24hi) stages
• B220+ cells markedly reduced, particularly in the follicular regions of the spleen
• reduced numbers of Cd21intCd24lo cells
• reduced numbers of Cd21hiCd23lo cells
• reduced follicular region size

hematopoietic system
• severely reduced numbers of splenic B cells in the T1(Cd21loCd24hi) and T2 (Cd21hiCd24hi) stages
• B220+ cells markedly reduced, particularly in the follicular regions of the spleen
• reduced numbers of Cd21intCd24lo cells
• reduced numbers of Cd21hiCd23lo cells
• reduced follicular region size





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory