Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
|
|
|
Misshapen cell nuclei in embryonic Lmnatm7Lgf/Lmnatm7Lgf fibroblasts
mortality/aging
N |
• mice exhibit normal survival
|
cellular
|
• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice and Lmnatm6Lgf homozygotes
• however, nuclear stiffness in fibroblalsts is normal
|
reproductive system
Allelic Composition |
Lmnatm7Lgf/Lmna+
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
|
|
|
Allelic Composition |
Lmnatm1Stw/Lmnatm7Lgf
|
|
Genetic Background |
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation
(3 available);
any
Lmna mutation
(82 available)
Lmnatm7Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
|
|
|
Allelic Composition |
Lmnatm2Lgf/Lmnatm7Lgf
|
|
Genetic Background |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm2Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
Lmnatm7Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm7Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
Zmpste24tm1Sgy mutation
(2 available);
any
Zmpste24 mutation
(32 available)
|
|
|
mortality/aging
N |
• mice exhibit normal survival
|
skeleton
|
• compared to in Zmpste24tm1Sgy homozygotes
|
growth/size/body