Analysis Tools
mortality/aging
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• all die perinatally
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embryo
| N |
• placental weight is normal
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Allele Symbol Allele Name Allele ID |
Meg3tm1Itl targeted mutation 1, inGenious Targeting Laboratory MGI:4840060 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all die perinatally
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| N |
• placental weight is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice inheriting the mutation maternally die perinatally with no milk in their stomachs and non-inflated lungs
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• in mice inheriting the mutation maternally, maternally expressed genes are silenced and paternally expressed genes are activated and both the maternal and paternal alleles of the nearby intergenic differentially methylated region and the differentially methylated region associated with the gene are methylated in embryos
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• in embryos inheriting the mutation maternally muscle maturation beyond the myotube stage is delayed
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• in mice inheriting the mutation maternally muscles consist mainly of myofibers with centrally localized nuclei or areas of central clearing characteristics of immature muscle fibers
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• lungs of neonates inheriting the mutation maternally fail to inflate
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• mice inheriting the mutation paternally weigh about 13.3% less than their wild-type littermates at E18.5
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• in mice inheriting the mutation paternally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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