Phenotypes associated with this allele

• Allele Symbol: Terf2ip^tm1.1Blas
• Allele Name: targeted mutation 1.1, Maria A Blasco
• Allele ID: MGI:4839729
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Terf2ip^tm1.1Blas/Terf2ip^tm1.1Blas	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:4839739
cn2	Terf2ip^tm1.1Blas/Terf2ip^tm1.1Blas Tg(KRT5-cre)1Tak/0	involves: 129S2/SvPas * C3H * C57BL/6 * SJL	MGI:4839738

Genotype
MGI:4839739

cn1

• Allelic Composition: Terf2ip^tm1.1Blas/Terf2ip^tm1.1Blas
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:165984 )

N • mouse embryonic fibroblasts transfected with cre exhibit normal proliferation and cell cycle

abnormal telomere morphology ( J:165984 )

• 70% of mouse embryonic fibroblasts transfected with cre exhibit more than three telomere dysfunction induced foci unlike wild-type cells

decreased telomere length ( J:165984 )

• mouse embryonic fibroblasts transfected with cre exhibit an increase in short telomeres and decreased long telomeres compared with wild-type cells

increased chromosomal stability ( J:165984 )

• mouse embryonic fibroblasts transfected with cre and treated with aphidicolin exhibit increased chromosome breaks and complex aberrations compared with similarly treated wild-type cells

Genotype
MGI:4839738

cn2

• Allelic Composition: Terf2ip^tm1.1Blas/Terf2ip^tm1.1Blas; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * SJL

cellular

abnormal telomere morphology ( J:165984 )

• telomeres in the epidermis is shorter than in wild-type cells with increased DNA damage

growth/size/body

increased body weight ( J:165984 )

• in female mice on a standard diet

pigmentation

hyperpigmentation ( J:165984 )

• in adulthood