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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prnp-TARDBP)4Jlel
transgene insertion 4, Jeffrey L Elliott
MGI:4839645
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Prnp-TARDBP)4Jlel/0 involves: C57BL/6 * CD-1 * SJL MGI:4839655


Genotype
MGI:4839655
tg1
Allelic
Composition
Tg(Prnp-TARDBP)4Jlel/0
Genetic
Background
involves: C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-TARDBP)4Jlel mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 109 days

muscle
• mice exhibit weakness that manifests as external rotation in one hindlimb followed by development of severe bilateral proximal weakness and hypotonia unlike wild-type mice
• muscles exhibit variation in muscle fiber size, prominent myopathic grouping, and disorganization of the myofiber internal architecture unlike wild-type muscles

behavior/neurological
• mice exhibit late onset, progressive motor defects compared with wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory