About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pknox1tm1Fbla
targeted mutation 1, Francesco Blasi
MGI:4839363
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pknox1tm1Fbla/Pknox1tm1Fbla B6.Cg-Pknox1tm1Fbla MGI:4839417
cx2
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Pknox1tm1Fbla/Pknox1tm1Fbla
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4839565
cx3
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Pknox1tm1Fbla/Pknox1tm1Fbla
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:4839469
cx4
Pknox1tm1Fbla/Pknox1tm1Fbla
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C57BL/6 MGI:4839564
cx5
Atmtm1Fwa/Atmtm1Fwa
Pknox1tm1Fbla/Pknox1+
involves: 129S4/SvJae * C57BL/6 MGI:4839470
cx6
Atmtm1Fwa/Atmtm1Fwa
Pknox1tm1Fbla/Pknox1tm1Fbla
involves: 129S4/SvJae * C57BL/6 MGI:4839471


Genotype
MGI:4839417
hm1
Allelic
Composition
Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic
Background
B6.Cg-Pknox1tm1Fbla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1tm1Fbla mutation (0 available); any Pknox1 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E7.5 to E7.75, no embryonic derivatives were detected by marker expression unlike in wild-type mice
• as determined by marker expression
• the number of Oct4+ cells is reduced at E6.75 through E8.5 by apoptosis compared to in wild-type mice
• as determined by marker expression
• at E7.5 to E7.75, marker expression determined that extra-embryonic compartments are restricted to residual cells of extra-embryonic endoderm and derivatives of visceral ectoderm unlike in wild-type mice
• absent as determined by marker expression

growth/size/body




Genotype
MGI:4839565
cx2
Allelic
Composition
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Pknox1tm1Fbla/Pknox1tm1Fbla
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation (2 available); any Cdkn2a mutation (29 available)
Pknox1tm1Fbla mutation (0 available); any Pknox1 mutation (73 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are recovered (no time of death given)




Genotype
MGI:4839469
cx3
Allelic
Composition
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation (2 available); any Cdkn2a mutation (29 available)
Pknox1tm1Fbla mutation (0 available); any Pknox1 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mice exhibit the same reduced Oct4 expression domain as in Pknox1tm1Fbla homozygotes




Genotype
MGI:4839564
cx4
Allelic
Composition
Pknox1tm1Fbla/Pknox1tm1Fbla
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1tm1Fbla mutation (0 available); any Pknox1 mutation (73 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are almost reabsorbed between E9.5 and E10.5

embryo
• anterior visceral endoderm and primitive streak formation are partially rescued compared to in Pknox1tm1Fbla homozygotes
• the Oct4 expression domain is expanded with a decrease in apoptosis compared to in Pknox1tm1Fbla homozygotes
• the extra-embryonic ectoderm is better organized than in Pknox1tm1Fbla homozygotes

growth/size/body




Genotype
MGI:4839470
cx5
Allelic
Composition
Atmtm1Fwa/Atmtm1Fwa
Pknox1tm1Fbla/Pknox1+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Fwa mutation (1 available); any Atm mutation (81 available)
Pknox1tm1Fbla mutation (0 available); any Pknox1 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• in 2 of 4 mice

growth/size/body
• in 2 of 4 mice




Genotype
MGI:4839471
cx6
Allelic
Composition
Atmtm1Fwa/Atmtm1Fwa
Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Fwa mutation (1 available); any Atm mutation (81 available)
Pknox1tm1Fbla mutation (0 available); any Pknox1 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• in the single mouse generated
• at E7.5, Oct4+ cells are almost undetectable in the single mouse generated

growth/size/body
• in the single mouse generated





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory