Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.2Lysa mutation
(0 available);
any
Fbn1 mutation
(171 available)
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Perturbed microfibril structure in Fbn1tm1.2Lysa/Fbn1tm1.2Lysa mice
mortality/aging
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• mice die between P9 and P18 with most mice dying at P14
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cardiovascular system
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• at 2 months, mice exhibit progressive fragmentation of the aortic elastic lamellae with age unlike wild-type mice
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skeleton
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
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muscle
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
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integument
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
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Allelic Composition |
Fbn1tm1.2Lysa/Fbn1+
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Genetic Background |
involves: C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.2Lysa mutation
(0 available);
any
Fbn1 mutation
(171 available)
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Fragmentation of aortic root elastic lamellae in Fbn1tm1.2Lysa/Fbn1+ mice
cardiovascular system
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• at 2 months, mice exhibit progressive fragmentation of the aortic elastic lamellae with age unlike wild-type mice
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muscle
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
• however, early postnatal assembly of microfibril networks is normal
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
• however, early postnatal assembly of microfibril networks is normal
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skeleton
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
• however, early postnatal assembly of microfibril networks is normal
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integument
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• at P8, mice exhibit fragmentation of the microfibril network unlike in wild-type mice
• however, early postnatal assembly of microfibril networks is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.2Lysa mutation
(0 available);
any
Fbn1 mutation
(171 available)
Fbn2tm1Rmz mutation
(1 available);
any
Fbn2 mutation
(142 available)
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mortality/aging
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• most mice die right after birth especially when the dam is homozygous for Fbn2tm1Rmz
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• especially when the dam is homozygous for Fbn2tm1Rmz
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