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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adam10tm2Psa
targeted mutation 2, Paul Saftig
MGI:4838238
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adam10tm2Psa/Adam10tm2Psa involves: 129P2/OlaHsd * C57BL/6J MGI:4838239
cn2
Adam10tm2Psa/Adam10tm2Psa
Tg(Serpinb7-icre)1Fech/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5474059
cn3
Adam10tm2Psa/Adam10tm2Psa
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4838242


Genotype
MGI:4838239
hm1
Allelic
Composition
Adam10tm2Psa/Adam10tm2Psa
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm2Psa mutation (1 available); any Adam10 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile




Genotype
MGI:5474059
cn2
Allelic
Composition
Adam10tm2Psa/Adam10tm2Psa
Tg(Serpinb7-icre)1Fech/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm2Psa mutation (1 available); any Adam10 mutation (5 available)
Tg(Serpinb7-icre)1Fech mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice do not show overt abnormalities, even though cre expression is detected in esophagus and the stomach; no differences in histology are detected in esophagus and glandular hindstomach relative to controls
• mice grow at similar rate to littermates, as shown by body weight measurements
• forestomach hypoplasia is detected with decreased depth of gastric pits in adult mice
• no digestive problems are observed




Genotype
MGI:4838242
cn3
Allelic
Composition
Adam10tm2Psa/Adam10tm2Psa
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm2Psa mutation (1 available); any Adam10 mutation (5 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only small number of mutant mice survived more than 12 h after birth

cardiovascular system
• seen in dying embryos
• macroscopically mutant embryos did not display gross abnormalities

nervous system
• seen in dying embryos
• macroscopically mutant embryos did not display gross abnormalities
• a premature differentiation of neural progenitor cells into postmitotic neuron
• reduction of the ganglionic eminence and disrupted organization of the cortical region in E15.5 and later embryos

embryo
• a premature differentiation of neural progenitor cells into postmitotic neuron





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory