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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sh2d3ctm1.1Ebp
targeted mutation 1.1, Elena Pasquale
MGI:4838039
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sh2d3ctm1.1Ebp/Sh2d3ctm1.1Ebp involves: C57BL/6 MGI:4838048


Genotype
MGI:4838048
hm1
Allelic
Composition
Sh2d3ctm1.1Ebp/Sh2d3ctm1.1Ebp
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d3ctm1.1Ebp mutation (0 available); any Sh2d3c mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die in the first day after birth (J:165694)
• however, mice that survive shortly after birth exhibit normal survival (J:165694)

reproductive system
• greatly in 3 of 8 surviving adult male mice

nervous system
• olfactory neurons grown in 3 dimensional extracellular matrix exhibit reduced outgrowth compared with similarly treated wild-type neurons
• at P0.5, fewer gonadotropin positive cells are found in the preoptic region of the hypothalamus compared to in wild-type mice
• olfactory bulbs exhibit severe defects in lamination compared with wild-type
• the nerve fiber layer is completely lost unlike in wild-type mice
• mice exhibit a lack of the stereotypic circular arrangement of interneurons in the glomerular layer unlike wild-type mice
• mice lack a distinct mitral cell layer unlike in wild-type mice
• in 23 of 25 mice at P0.5
• by E13.5, olfactory sensory neuron axons exhibit impaired ability to reach the developing olfactory bulb stalling outside the pial basement membrane unlike in wild-type mice
• by E13.5, olfactory sensory neuron axons exhibit impaired ability to reach the developing olfactory bulb stalling outside the pial basement membrane unlike in wild-type mice
• at P0.5, mice exhibit deficient innervation in the olfactory bulb compared with wild-type mice
• at P0.5, the olfactory bulb exhibits increased apoptosis in the epithelium compared to in wild-type mice
• however, no increase in apoptosis is observed at E14.5

behavior/neurological

endocrine/exocrine glands
• greatly in 3 of 8 surviving adult male mice

cellular
• olfactory neurons grown in 3 dimensional extracellular matrix exhibit reduced outgrowth compared with similarly treated wild-type neurons





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory