Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip5k1ctm1.2Ref mutation
(0 available);
any
Pip5k1c mutation
(41 available)
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mortality/aging
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N |
• mice are born in Mendelian ratios
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nervous system
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• defective synaptic vesicle endocytosis
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behavior/neurological
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• reduced magnitude of response, also at several prepulse intensities
• however, mice exhibit normal prepulse inhibition
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cellular
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• agonist-induced calcium signaling is enhanced in fibroblasts compared with wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip5k1ctm1.2Ref mutation
(0 available);
any
Pip5k1c mutation
(41 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
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immune system
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• adhesion to ICAM-1 is increased compared to in wild-type cells
• T cell-APC conjugate formation is decreased compared to in wild-type cells
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• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells
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• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies
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• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies
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hematopoietic system
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• adhesion to ICAM-1 is increased compared to in wild-type cells
• T cell-APC conjugate formation is decreased compared to in wild-type cells
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• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells
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cellular
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• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells
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Analysis Tools