Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation
(0 available);
any
Fev mutation
(14 available)
Fevtm2Esd mutation
(0 available);
any
Fev mutation
(14 available)
Tg(Fev-cre/ERT2)aEsd mutation
(0 available)
|
|
|
behavior/neurological
|
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time and make fewer entrances into the open arms of an elevated plus maze
• however, the level of exploratory behavior in the elevated plus maze is normal
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend more time in the dark chamber in a light dark exploration assay
|
|
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time in the center of an open field
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation
(0 available);
any
Fev mutation
(14 available)
Fevtm2Esd mutation
(0 available);
any
Fev mutation
(14 available)
Tg(Fev-cre)1Esd mutation
(1 available)
|
|
|
nervous system
N |
• unlike germline null mice, the number of serotonergic neurons is normal at E11.5 and E12.5
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation
(0 available);
any
Fev mutation
(14 available)
Fevtm2Esd mutation
(0 available);
any
Fev mutation
(14 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation
(11 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Fev-cre)1Esd mutation
(1 available)
|
|
|
nervous system
|
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
|
|
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
|
|
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
|
|
• neither high nor low concentrations of 8-Hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) elicit a change in baseline currents in labeled 5HT neurons
|
|
• YFP+ cells show increased spontaneous firing of action potentials
|