About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cxcr4tm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:4836915
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd MGI:4836916


Genotype
MGI:4836916
cn1
Allelic
Composition
Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Yiw mutation (5 available); any Cxcr4 mutation (32 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
• thymocytes numbers are significantly reduced

immune system
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
• thymocytes numbers are significantly reduced
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

skeleton
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

cellular
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

endocrine/exocrine glands
• thymocytes numbers are significantly reduced





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2022
MGI 6.21
The Jackson Laboratory