About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTV-PTGS2)#Thla
transgene insertion, Timothy Hla
MGI:4834855
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ptger2tm1Brey/Ptger2tm1Brey
Tg(MMTV-PTGS2)#Thla/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N MGI:4834864
tg2
Tg(MMTV-PTGS2)#Thla/0 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N MGI:4834865
tg3
Tg(MMTV-PTGS2)#Thla/0 involves: CD-1 MGI:4834866


Genotype
MGI:4834864
cx1
Allelic
Composition
Ptger2tm1Brey/Ptger2tm1Brey
Tg(MMTV-PTGS2)#Thla/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation (4 available); any Ptger2 mutation (31 available)
Tg(MMTV-PTGS2)#Thla mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• unlike transgenic mice wild-type for Ptger2, 12 week old virgin females do not display precocious mammary gland development
• in contrast to transgenic mice wild-type for Ptger2, few multiparous females develop mammary gland hyperplasia




Genotype
MGI:4834865
tg2
Allelic
Composition
Tg(MMTV-PTGS2)#Thla/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• virgin females display precocious development at 12 weeks of age
• seen in multiparous females

integument
• virgin females display precocious development at 12 weeks of age
• seen in multiparous females




Genotype
MGI:4834866
tg3
Allelic
Composition
Tg(MMTV-PTGS2)#Thla/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in some cases mammary gland adenomatous carcinomas metastasize to peripheral lymph nodes
• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females

endocrine/exocrine glands
• delay in the early stages of involution
• however, by 7 days post weaning mammary glands are regressed
• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
• hyperplastic alveolar nodules are seen with high frequency in multiparous females
• alveolar hyperplasia, squamous metaplasia, and adenomatous carcinomas of the mammary epithelial cells contribute to these lesions

integument
• delay in the early stages of involution
• however, by 7 days post weaning mammary glands are regressed
• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
• hyperplastic alveolar nodules are seen with high frequency in multiparous females
• alveolar hyperplasia, squamous metaplasia, and adenomatous carcinomas of the mammary epithelial cells contribute to these lesions





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory