Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
Tg(MMTV-PTGS2)#Thla mutation
(0 available)
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reproductive system
N |
• unlike transgenic mice wild-type for Ptger2, 12 week old virgin females do not display precocious mammary gland development
• in contrast to transgenic mice wild-type for Ptger2, few multiparous females develop mammary gland hyperplasia
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Allelic Composition |
Tg(MMTV-PTGS2)#Thla/0
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Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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endocrine/exocrine glands
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• virgin females display precocious development at 12 weeks of age
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• seen in multiparous females
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integument
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• virgin females display precocious development at 12 weeks of age
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• seen in multiparous females
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• in some cases mammary gland adenomatous carcinomas metastasize to peripheral lymph nodes
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• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
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endocrine/exocrine glands
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• delay in the early stages of involution
• however, by 7 days post weaning mammary glands are regressed
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• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
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• hyperplastic alveolar nodules are seen with high frequency in multiparous females
• alveolar hyperplasia, squamous metaplasia, and adenomatous carcinomas of the mammary epithelial cells contribute to these lesions
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integument
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• delay in the early stages of involution
• however, by 7 days post weaning mammary glands are regressed
|
|
• adenomatous carcinomas of the mammary epithelial cells contribute the hyperplastic alveolar nodules that are seen with high frequency in multiparous females
|
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• hyperplastic alveolar nodules are seen with high frequency in multiparous females
• alveolar hyperplasia, squamous metaplasia, and adenomatous carcinomas of the mammary epithelial cells contribute to these lesions
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