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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trip11m1Mawa
mutation 1, Matthew Warman
MGI:4829605
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trip11m1Mawa/Trip11m1Mawa C57BL/6J-Trip11m1Mawa MGI:4829609
cx2
Trip11m1Mawa/Trip11m1Mawa
Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N MGI:4889075


Genotype
MGI:4829609
hm1
Allelic
Composition
Trip11m1Mawa/Trip11m1Mawa
Genetic
Background
C57BL/6J-Trip11m1Mawa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip11m1Mawa mutation (0 available); any Trip11 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

skeleton
• at E15.5, no proliferating chondrocytes are observed at the center of the epiphysis or in the presumptive columnar zone in the humeri unlike in wild-type mice (J:163656)
• at E15.5, no proliferating chondrocytes are observed at the center of the epiphysis or in the presumptive columnar zone in the humeri unlike in wild-type mice (J:163656)
• osteoblasts exhibit swelling of the endoplasmic reticulum unlike in wild-type cells (J:163656)
• osteoblasts exhibit swelling of the endoplasmic reticulum unlike in wild-type cells (J:163656)
• at E13.5, hypertrophic chondrocytes are smaller than in wild-type mice (J:163656)
• at E13.5, proliferating chrondrocytes are larger than in wild-type mice (J:163656)
• at E15.5, chondrocytes fail to form an organized columnar growth zone compared with wild-type mice (J:163656)
• the chondrocyte hypertrophic differentiation is delayed compared to in wild-type mice and absent at E18.5 (J:163656)
• chondrocytes exhibit swelling of the endoplasmic reticulum and abnormal golgi unlike in wild-type cells (J:163656)
• at E13.5, hypertrophic chondrocytes are smaller than in wild-type mice (J:163656)
• at E13.5, proliferating chrondrocytes are larger than in wild-type mice (J:163656)
• at E15.5, chondrocytes fail to form an organized columnar growth zone compared with wild-type mice (J:163656)
• the chondrocyte hypertrophic differentiation is delayed compared to in wild-type mice and absent at E18.5 (J:163656)
• chondrocytes exhibit swelling of the endoplasmic reticulum and abnormal golgi unlike in wild-type cells (J:163656)
• intramembranous and endochondral bone mineralization is delayed compared to in wild-type mice (J:163656)
• intramembranous and endochondral bone mineralization is delayed compared to in wild-type mice (J:163656)
• mice lack vertebral-body ossification unlike wild-type mice (J:163656)
• mice lack vertebral-body ossification unlike wild-type mice (J:163656)
• at E15.5, chondrocytes produce less extracellular matrix compared to wild-type cells (J:163656)
• at E15.5, no proliferating chondrocytes are observed at the center of the epiphysis or in the presumptive columnar zone in the humeri unlike in wild-type mice (J:163656)
• at E17.5, apoptotic chondrocytes are detected in the humeri unlike in wild-type mice (J:163656)
• at E15.5, chondrocytes produce less extracellular matrix compared to wild-type cells (J:163656)
• at E15.5, no proliferating chondrocytes are observed at the center of the epiphysis or in the presumptive columnar zone in the humeri unlike in wild-type mice (J:163656)
• at E17.5, apoptotic chondrocytes are detected in the humeri unlike in wild-type mice (J:163656)

cellular
• mice exhibit swelling of the endoplasmic reticulum (ER) in the chondrocytes and osteoblasts unlike in wild-type cells (J:163656)
• however, the ER of other cells is normal (J:163656)
• mice exhibit swelling of the endoplasmic reticulum (ER) in the chondrocytes and osteoblasts unlike in wild-type cells (J:163656)
• however, the ER of other cells is normal (J:163656)
• post-translational protein processing and secretion in primary skin fibroblasts is impaired compared to in wild-type cells (J:163656)
• post-translational protein processing and secretion in primary skin fibroblasts is impaired compared to in wild-type cells (J:163656)

respiratory system
• alveolar formation in the lungs is decreased compared to in wild-type mice (J:163656)
• alveolar formation in the lungs is decreased compared to in wild-type mice (J:163656)

growth/size/body

craniofacial

limbs/digits/tail

Mouse Models of Human Disease
OMIM ID Ref(s)
Achondrogenesis, Type IA; ACG1A 200600 J:163656




Genotype
MGI:4889075
cx2
Allelic
Composition
Trip11m1Mawa/Trip11m1Mawa
Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic
Background
involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mbp-MAPT/lacZ)#aCaw mutation (0 available)
Trip11m1Mawa mutation (0 available); any Trip11 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
N
• mice exhibit normal thalamocortical axons (J:168258)
• mice exhibit normal thalamocortical axons (J:168258)
• slightly small (J:168258)
• slightly small (J:168258)
• slightly small (J:168258)
• slightly small (J:168258)

growth/size/body

limbs/digits/tail





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory