Phenotypes associated with this allele

• Allele Symbol: Cyld^tm1.1Gmos
• Allele Name: targeted mutation 1.1, George Mosialos
• Allele ID: MGI:4819959
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyld^tm1.1Gmos/Cyld^tm1.1Gmos	involves: BALB/cJ	MGI:4819963

Genotype
MGI:4819963

hm1

• Allelic Composition: Cyld^tm1.1Gmos/Cyld^tm1.1Gmos
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:162840 )

respiratory system

abnormal lung development ( J:162840 )

• primitive lung saccules fail to expand and contain abundant mesenchyme unlike in wild-type mice

• however, mice exhibit type II cells, Clara cells, and muscular and vascular structures

thick lung-associated mesenchyme ( J:162840 )

• lungs fail to exhibit thinning of the mesenchyme unlike in wild-type mice

abnormal lung interstitium morphology ( J:162840 )

• lung interstitial spaces are thicker and more densely populated by mesenchyme than in wild-type mice

small lung ( J:162840 )

• slightly at E18.5

atelectasis ( J:162840 )

abnormal respiratory function ( J:162840 )

limbs/digits/tail

short tail ( J:162840 )

kinked tail ( J:162840 )

cellular

impaired fibroblast cell migration ( J:162840 )

• nocodazole-treated fibroblasts exhibit impaired cell migration compared with similarly treated wild-type cells

growth/size/body

decreased birth body size ( J:162840 )

homeostasis/metabolism

cyanosis ( J:162840 )